Identifying biomarkers for endometriosis using menstrual blood

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify diagnostic and prognostic biomarkers for endometriosis by analyzing menstrual blood, a readily accessible biological fluid. Women aged 18-45, both with and without endometriosis, will provide menstrual blood samples using a menstrual cup, with some participants also undergoing surgery for their condition. The study will compare the menstrual blood of women affected by endometriosis to those without the condition, as well as before and after surgical treatment, to identify significant differences that could aid in diagnosis and prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For all participants:

Women 18-45 of age who

* Have their period
* Have given their written consent
* Have already used a menstrual cup as a method of hygienic protection
* Residing or working in Ile de France (Paris Metropolitan area, France)

For participants with endometriosis:

* diagnosis of endometriosis established by surgery or imaging (ultrasound and/or MRI)
* presence of one or more painful symptoms \> 3 on a visual scale (dysmenorrhea and/or dyspareunia and/or chronic pelvic pain) and/or infertility
* for the surgery subgroup: planned surgery in the next 3 months

For participants without endometriosis:

* painful symptoms \< or equal to 3 on a visual scale (for dysmenorrhea and dyspareunia and chronic pelvic pain),
* absence of intense period pain in adolescence (leading to taking pills to control this pain and/or peri-menstrual school absenteeism)

Exclusion Criteria:

For all participants:

* Autoimmune diseases
* Chronic diseases other than endometriosis (diabetes, hypertension)
* A person who is the subject of a judicial safeguard measure (by declaration)
* Infectious diseases (HIV, HBV, if known)
* History of menstrual toxic shock syndrome

For patients with endometriosis:

* endometriosis surgery within the last 3 months.

Where it's running

• Hopital Cochin
  Paris, France Recruiting

Study contacts

• Principal investigator: Louis Marcellin — Institut National de la Santé Et de la Recherche Médicale, France
• Study coordinator: Ludivine Doridot
• Email: ludivine.doridot@inserm.fr
• Phone: 33(0)1 40 51 64 33

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing different techniques to treat endometriosis

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• Postoperative Pain Trajectories After Endometriosis Surgery

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• Imaging endometriosis with a special PET tracer in adult women

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  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07876648

• Fiber supplement for digestive symptoms in endometriosis

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  Recruiting LOAM Science · San Francisco, California · NCT07875062

• Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy

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• Atypical Endometriosis: Histology, Immunophenotype and Molecular Features

  Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07816133

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.