Non-invasive menstrual biomarker test for endometriosis in infertility patients
Official title: Performance evaluation of a non-invasive menstrual test for endometriosis in infertility patients
Funded at Nextgenjane, INC. · NIH-11321735 · Data updated 2026-11-12
A non-invasive test using menstrual fluid is being developed to help diagnose endometriosis in people dealing with infertility.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nextgenjane, INC. NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | April 15, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $714,095 |
| NIH project number | 5R44HD118899-02 |
| Project ID | NIH-11321735 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infertility patients suspected of having endometriosis who are potential candidates for non-surgical diagnostic testing.
✕Less likely to help
Patients with endometriosis who may not be diagnosed by this biomarker or whose fertility plans are not impacted by diagnostic timing.
What this research studies
Endometriosis often goes undiagnosed for years and current diagnosis relies on surgery, which is costly and has long recovery. This project tests a genomic biomarker in menstrual fluid to aid diagnosis without invasive procedures. If successful, the test could speed up detection and improve fertility planning for patients. The research is conducted by NextGenJane, Inc. in Oakland and aims to bring a practical diagnostic tool closer to clinical use.
Why it matters
Potential benefit: If successful, patients could get a quicker, less invasive diagnosis that informs treatment and improves fertility outcomes.
How similar studies have gone: Preliminary data show a high-performance genomic assay in menstrual blood, suggesting promise for a non-invasive diagnosis.
Where this research is happening
-
Nextgenjane, INC.
Oakland, United States Active
Researchers
- Principal investigator: Gire, Stephen — Nextgenjane, INC.
- Study coordinator: Gire, Stephen
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
A new non-invasive test for diagnosing endometriosis in women facing infertility
This study is working on a simple and non-invasive test using menstrual fluid to help diagnose endometriosis earlier, which could make it easier for women to get the care they need and improve their chances of having children.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Oral FSH receptor activator drugs to lower infertility treatment costs
A new oral drug approach aims to improve fertility treatments by using a small molecule that activates the FSH receptor, potentially making infertility care more affordable.
-
Prediction of ART outcomes for male factor infertility using single-molecule chromatin stenciling in sperm
A new test called sperm Fiber-seq is being developed to better predict how well ART will work for couples dealing with male-factor infertility.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.