Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Official title: Endometriosis "Atypical" and Cancerized: Anatomopathological and Clinical-instrumental Characterization on the Ultrasound and Biological Characteristics of Atypical Endometriosis.
Run by Casa di Cura Dott. Pederzoli · NCT07816133 · Data updated 2026-11-12
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 200 (estimated) |
| Sponsor | Casa di Cura Dott. Pederzoli Academic / other |
| Locations | 1 site (Peschiera del Garda, Verona) |
| Status | Recruiting |
| Started | October 2026 |
| Main results expected | January 2029 |
| Study ends | June 2029 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT07816133 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older undergoing endometriosis-related surgery or biopsies with available ultrasound data and informed consent.
✕Probably not a fit
Patients whose lesions remain benign and non-atypical may not experience a direct benefit, though findings may advance knowledge.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study analyzes tissue from patients undergoing laparoscopic surgery for endometriosis or related conditions to characterize histology, immunophenotype, and molecular features. It combines retrospective and prospective data from a single center, with two comparison groups: endometriosis without atypia and neoplasia not associated with endometriosis as controls, and atypical or cancerized endometriosis as cases. Data collection aligns with routine clinical practice and includes ultrasound findings and anatomopathological analyses. The study aims to generate hypotheses about how atypical changes may progress toward malignancy and how ultrasound and molecular markers could aid risk stratification.
Why it matters
Potential benefit: If successful, the study could improve risk stratification and inform future management of endometriosis with atypical features.
How similar studies have gone: Previous research in related areas has reported meaningful insights from combined histology and imaging analyses in endometriosis, though this exact atypical focus is less established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Candidate patients for endometriosis surgery with deep endometriosis (intestine, LUS) and/or endometrioma localizations. * Patients who are candidates for surgery for established or suspected endometrial and/or ovarian neoplasm * Patients who have performed a level II gynecological ultrasound with an experienced operator in the preoperative process. * Patients where there is the technical possibility of performing a transvaginal and/or transrectal ultrasound and the patient's willingness to undergo such an investigation. * Signing of informed consent. Exclusion Criteria: * Technical impossibility of performing a transvaginal ultrasound (patient virgo, patient refusal). * Previous neoplasms * Patient who does not provide their informed consent.
Where it's running
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Ospedale P. Pederzoli Casa di Cura Privata S.p.A.
Peschiera del Garda, Verona, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.