Comparing different techniques to treat endometriosis
Official title: Histologic Comparison of Ablative Techniques for Endometriosis - a Randomized Trial
Run by TriHealth Inc. · NCT06414083 · Data updated 2026-11-12
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 141 (estimated) |
| Sponsor | TriHealth Inc. Academic / other |
| Locations | 1 site (Cincinnati, Ohio) |
| Status | Recruiting |
| Started | May 9, 2024 |
| Main results expected | May 9, 2025 |
| Study ends | June 9, 2025 |
| Registry record updated | May 30, 2024 |
| Trial ID | NCT06414083 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult women aged 18 and older who are planning to undergo surgery for endometriosis-related symptoms.
✕Probably not a fit
Patients who are pregnant at the time of enrollment or surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to directly compare the effectiveness of various ablative techniques, including diathermy, CO2 laser, and argon beam coagulator, in treating endometriosis. By evaluating their ability to destroy native endometriosis tissue in human subjects, the research seeks to identify the most effective method for alleviating endometriosis-related pain. The study will involve adult women who are already scheduled for robotic-assisted or laparoscopic excision of endometriosis lesions. This comparison is significant as it addresses a gap in existing research regarding the effectiveness of these technologies.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment options for women suffering from endometriosis and its associated pain.
How similar studies have gone: This study is novel as there have been no direct comparisons of these ablative techniques in human subjects to date.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult women 18 years of age or older * Already planning to undergo scheduled robotic assisted or laparoscopic excision of lesions for pelvic pain symptoms (pelvic pain, dysmenorrhea, dyspareunia, dysuria, dyschezia, ovarian pain) or endometriosis of any kind (endometriosis of any location, or endometrioma) Exclusion Criteria: * Known pregnancy at enrollment or at the time of the excision surgery
Where it's running
-
Good Samaritan Hospital
Cincinnati, Ohio, United States Recruiting
Study contacts
- Study coordinator: Devin Namaky, MD
- Email: devin_namaky@trihealth.com
- Phone: 513-862-1888
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Evaluating physical therapy for endometriosis pain management
This study is testing if a mix of education about pain and specific exercises can help women with endometriosis feel less pain and improve their quality of life.
-
Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
-
Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
-
Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
-
Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
-
Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.