Non-invasive treatment for chronic pelvic pain from endometriosis
Official title: Treatment of Chronic Pelvic Pain Due to Endometriosis by Transcutaneous Auricular Vagus Nerve Stimulation
Run by Hopital Foch · NCT04177511 · Data updated 2026-11-12
This study is testing a new non-invasive treatment using nerve stimulation to see if it can help women with chronic pelvic pain from endometriosis feel better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years and up |
| Sex | Women only |
| Enrollment | 72 (estimated) |
| Sponsor | Hopital Foch Academic / other |
| Locations | 1 site (Suresnes, Île-de-France Region) |
| Status | Recruiting |
| Started | December 13, 2021 |
| Main results expected | March 28, 2027 |
| Study ends | March 28, 2027 |
| Registry record updated | November 21, 2025 |
| Trial ID | NCT04177511 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 15 and older diagnosed with endometriosis and experiencing chronic pelvic pain.
✕Probably not a fit
Patients with contraindications to vagus nerve stimulation, such as certain cardiac conditions or those who are pregnant or breastfeeding, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the use of transcutaneous auricular vagus nerve stimulation as a treatment for chronic pelvic pain associated with endometriosis. The study targets women aged 15 and older who experience symptoms such as dysmenorrhea and dyspareunia, despite previous treatments. The approach aims to leverage the anti-inflammatory effects and neurotransmitter modulation provided by vagus nerve stimulation to alleviate pain. Participants will be monitored for effectiveness and safety throughout the intervention.
Why it matters
Potential benefit: If successful, this treatment could provide a non-invasive option for women suffering from chronic pelvic pain due to endometriosis.
How similar studies have gone: While vagus nerve stimulation has shown promise in treating conditions like migraine and depression, this specific application for endometriosis-related pain is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged \>= 15 years * With chronic pelvic pain and/ or dysmenorrhoea and/ or dyspareunia * Who has been cared for by a gynecologist in one of the institutions participating in the study * Diagnosed with endometriosis * Having signed an informed written consent * Affiliated to a health insurance scheme Exclusion Criteria: * contraindication to the use of transcutaneous auricular vagus nerve stimulation (cardiac pathology, asthmatic patient) * pregnant or breastfeeding women * patient undergoing in vitro fertilization * associated pathology requiring long-term analgesic treatment * patient with atria trans vagal neurostimulation in the 12 months prior to inclusion * patient deprived of liberty or under guardianship
Where it's running
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Hopital Foch
Suresnes, Île-de-France Region, France Recruiting
Study contacts
- Principal investigator: Mireille MICHEL-CHERQUI, MD — Hopital Foch, Suresnes
- Study coordinator: Mireille MICHEL-CHERQUI, MD
- Email: drci.promotion@hopital-foch.com
- Phone: 0033 1 46 25 29 85
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Comparing different techniques to treat endometriosis
This study is testing different methods to treat endometriosis, like laser and heat techniques, to see which one works best for relieving pain in women who are already having surgery for the condition.
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Postoperative Pain Trajectories After Endometriosis Surgery
This study tests how pain changes after endometriosis surgery and whether perioperative pain testing can predict who will have ongoing pain.
-
Imaging endometriosis with a special PET tracer in adult women
This study tests whether a PET/CT scan using [18F]AlF-FAPI-74 can help detect endometriosis lesions in women who are planning laparoscopy.
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Fiber supplement for digestive symptoms in endometriosis
A fiber-based supplement is being tested to see if it is safe and helps with gut and vaginal microbiomes and digestive symptoms in women with endometriosis.
-
Stellate ganglion block and dexmedetomidine for better sleep after gynecologic laparoscopy
The study tests whether giving a preoperative stellate ganglion block plus intraoperative dexmedetomidine improves sleep after laparoscopic gynecologic surgery in women.
-
Atypical Endometriosis: Histology, Immunophenotype and Molecular Features
Researchers will look at how endometriotic tissue that looks atypical under the microscope relates to clinical features and ultrasound findings to better separate benign from potentially atypical lesions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.