Investigating inflammatory factors in acute kidney injury among ICU patients
Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury
This study is trying to see if certain inflammation markers can help us understand why some ICU patients develop acute kidney injury, especially those with sepsis or who have had major surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Uppsala University Academic / other |
| Locations | 1 site (Uppsala, Uppsala County) |
| Trial ID | NCT03720860 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the role of inflammatory mediators in the development of acute kidney injury (AKI) in patients admitted to intensive care units. It focuses on patients with sepsis, those who have undergone major surgery, and non-inflamed individuals to identify novel inflammatory markers associated with AKI risk. By correlating these inflammatory levels with patient outcomes, the study seeks to enhance understanding of the mechanisms behind sepsis-induced AKI. The findings could lead to improved management strategies for at-risk patients.
Who should consider this trial
Good fit: Ideal candidates include patients admitted to intensive or postoperative care units with septic shock, post-major surgery, or after chemical intoxication.
Not a fit: Patients who are pregnant, breastfeeding, have chronic kidney disease, or have been exposed to nephrotoxic compounds may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better identification and management of patients at risk for acute kidney injury, potentially reducing mortality rates.
How similar studies have performed: While the specific approach of this study is novel, previous research has indicated a link between inflammation and acute kidney injury, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients admitted to the intensive/post operative care unit * with septic shock or * post major surgery or * after intoxication with a chemical compund Exclusion Criteria: * Pregnancy or * Breast feeding or * Chronic kidney disease or * intoxication with nephrotoxic compund or * lack of informed consent
Where this trial is running
Uppsala, Uppsala County
- Akademiska sjukhuset, Centraloperation — Uppsala, Uppsala County, Sweden (Recruiting)
Study contacts
- Study coordinator: Sara Bulow, MD
- Email: sara.bulow.anderberg@akademiska.se
- Phone: +46730247414
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.