Investigating inflammatory factors in acute kidney injury among ICU patients
Official title: Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury
Run by Uppsala University · NCT03720860 · Data updated 2026-11-12
This study is trying to see if certain inflammation markers can help us understand why some ICU patients develop acute kidney injury, especially those with sepsis or who have had major surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Uppsala University Academic / other |
| Locations | 1 site (Uppsala, Uppsala County) |
| Status | Recruiting |
| Started | January 1, 2018 |
| Main results expected | May 2026 |
| Study ends | May 2026 |
| Registry record updated | January 12, 2026 |
| Trial ID | NCT03720860 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients admitted to intensive or postoperative care units with septic shock, post-major surgery, or after chemical intoxication.
✕Probably not a fit
Patients who are pregnant, breastfeeding, have chronic kidney disease, or have been exposed to nephrotoxic compounds may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the role of inflammatory mediators in the development of acute kidney injury (AKI) in patients admitted to intensive care units. It focuses on patients with sepsis, those who have undergone major surgery, and non-inflamed individuals to identify novel inflammatory markers associated with AKI risk. By correlating these inflammatory levels with patient outcomes, the study seeks to enhance understanding of the mechanisms behind sepsis-induced AKI. The findings could lead to improved management strategies for at-risk patients.
Why it matters
Potential benefit: If successful, this study could lead to better identification and management of patients at risk for acute kidney injury, potentially reducing mortality rates.
How similar studies have gone: While the specific approach of this study is novel, previous research has indicated a link between inflammation and acute kidney injury, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients admitted to the intensive/post operative care unit * with septic shock or * post major surgery or * after intoxication with a chemical compund Exclusion Criteria: * Pregnancy or * Breast feeding or * Chronic kidney disease or * intoxication with nephrotoxic compund or * lack of informed consent
Where it's running
-
Akademiska sjukhuset, Centraloperation
Uppsala, Uppsala County, Sweden Recruiting
Study contacts
- Study coordinator: Sara Bulow, MD
- Email: sara.bulow.anderberg@akademiska.se
- Phone: +46730247414
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.