Clinical trial Recruiting at 1 site Observational Ages 18 and up

Investigating inflammatory factors in acute kidney injury among ICU patients

Official title: Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury

Run by Uppsala University · NCT03720860 · Data updated 2026-11-12

This study is trying to see if certain inflammation markers can help us understand why some ICU patients develop acute kidney injury, especially those with sepsis or who have had major surgery.

More Sepsis trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUppsala University
Academic / other
Locations1 site (Uppsala, Uppsala County)
StatusRecruiting
StartedJanuary 1, 2018
Main results expectedMay 2026
Study endsMay 2026
Registry record updatedJanuary 12, 2026
Trial IDNCT03720860 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients admitted to intensive or postoperative care units with septic shock, post-major surgery, or after chemical intoxication.

Probably not a fit

Patients who are pregnant, breastfeeding, have chronic kidney disease, or have been exposed to nephrotoxic compounds may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the role of inflammatory mediators in the development of acute kidney injury (AKI) in patients admitted to intensive care units. It focuses on patients with sepsis, those who have undergone major surgery, and non-inflamed individuals to identify novel inflammatory markers associated with AKI risk. By correlating these inflammatory levels with patient outcomes, the study seeks to enhance understanding of the mechanisms behind sepsis-induced AKI. The findings could lead to improved management strategies for at-risk patients.

Why it matters

Potential benefit: If successful, this study could lead to better identification and management of patients at risk for acute kidney injury, potentially reducing mortality rates.

How similar studies have gone: While the specific approach of this study is novel, previous research has indicated a link between inflammation and acute kidney injury, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Patients admitted to the intensive/post operative care unit

* with septic shock or
* post major surgery or
* after intoxication with a chemical compund

Exclusion Criteria:

* Pregnancy or
* Breast feeding or
* Chronic kidney disease or
* intoxication with nephrotoxic compund or
* lack of informed consent

Where it's running

  • Akademiska sjukhuset, Centraloperation
    Uppsala, Uppsala County, Sweden
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.