Investigating how a protein affects kidney injury and metabolism
Official title: The role of transcriptional corepressor CtBP2 as a metabolic sensor in acute kidney injury
Funded at Ohio State University · NIH-11174187 · Data updated 2026-11-12
This study is looking at how a protein called CtBP2 affects kidney damage in people with acute kidney injury (AKI) and aims to find new ways to protect kidney function by understanding how energy changes in the body contribute to this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 17, 2024 |
| Project end | September 16, 2025 |
| Funding year | 2024 |
| Award (this year) | $199,990 |
| NIH project number | 1R56DK140315-01 |
| Project ID | NIH-11174187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are hospitalized patients at risk of acute kidney injury, particularly those with conditions that may lead to kidney stress.
✕Less likely to help
Patients with stable kidney function and no history of acute kidney injury are unlikely to benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called CtBP2 in acute kidney injury (AKI), a serious condition that can occur in hospitalized patients. The study aims to explore how changes in energy metabolism, specifically involving a molecule called NAD+, contribute to kidney damage during AKI. By examining the effects of inhibiting CtBP2 in various models of kidney injury, the researchers hope to identify new therapeutic strategies that could protect kidney function and improve patient outcomes. This work involves advanced techniques like ChIP-seq to analyze gene expression related to kidney health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate acute kidney injury, ultimately improving recovery and reducing the risk of chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in kidney injury, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Kim, Jiyoung — Ohio State University
- Study coordinator: Kim, Jiyoung
Related research
Other NIH-funded projects on the same topics.
-
SEAK Alliance: Improving Care for AKI Patients in the Southeast
A national, patient-centered effort to improve post-hospital care for people who had acute kidney injury in the Southeast.
-
AKI-related delirium after heart surgery
This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.
-
Better ways to identify types of sudden kidney injury in U.S. Veterans
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-
Neuroimmune control of kidney injury using noninvasive ultrasound
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Structure-based approach to prevent kidney injury from polymyxin use
Aims to block how polymyxin damages the kidney so it can be used more safely to treat hard-to-kill infections.
-
Using smart computer predictions to prevent kidney injury after heart surgery
A machine-learning approach uses routinely collected hospital data to predict who might develop acute kidney injury after heart surgery, so clinicians can act early.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.