Investigating how a protein affects kidney injury and metabolism
The role of transcriptional corepressor CtBP2 as a metabolic sensor in acute kidney injury
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-11174187
This study is looking at how a protein called CtBP2 affects kidney damage in people with acute kidney injury (AKI) and aims to find new ways to protect kidney function by understanding how energy changes in the body contribute to this condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11174187 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called CtBP2 in acute kidney injury (AKI), a serious condition that can occur in hospitalized patients. The study aims to explore how changes in energy metabolism, specifically involving a molecule called NAD+, contribute to kidney damage during AKI. By examining the effects of inhibiting CtBP2 in various models of kidney injury, the researchers hope to identify new therapeutic strategies that could protect kidney function and improve patient outcomes. This work involves advanced techniques like ChIP-seq to analyze gene expression related to kidney health.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized patients at risk of acute kidney injury, particularly those with conditions that may lead to kidney stress.
Not a fit: Patients with stable kidney function and no history of acute kidney injury are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or mitigate acute kidney injury, ultimately improving recovery and reducing the risk of chronic kidney disease.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in kidney injury, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, JIYOUNG — OHIO STATE UNIVERSITY
- Study coordinator: KIM, JIYOUNG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.