Illuminating human kidney injury with advanced tissue imaging
Official title: Spatial Elucidation of Human Acute Kidney Injury and Chronic Kidney Disease using Imaging Mass Cytometry
Funded at Yale University · NIH-11378497 · Data updated 2026-11-12
This grant helps researchers map kidney injury in people by using a powerful imaging technique on kidney biopsy tissue to reveal cellular details that could guide better treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $306,691 |
| NIH project number | 5U01DK133768-05 |
| Project ID | NIH-11378497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute kidney injury who are willing to provide kidney biopsy tissue for research.
✕Less likely to help
Patients who do not have AKI or who are unable to provide biopsy samples may not directly benefit.
What this research studies
The project uses Imaging Mass Cytometry to create a detailed cellular map from human kidney biopsies of patients with acute kidney injury and links this data with other molecular information. By studying the cells, their states, and repair pathways in human tissue, researchers hope to uncover why AKI progresses and how CKD develops after injury. The effort builds on the Kidney Precision Medicine Project and integrates multiple data types to build a comprehensive view of human kidney disease. Participants contribute kidney tissue samples to advance science that may lead to targeted therapies in the future.
Why it matters
Potential benefit: If successful, the work could lead to more precise diagnoses and new treatment strategies for AKI and CKD in patients.
How similar studies have gone: Previous collaborations have shown that tissue-based, multi-omics approaches can reveal actionable insights into kidney disease.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Kakade, Vijayakumar Raghurama Rao — Yale University
- Study coordinator: Kakade, Vijayakumar Raghurama Rao
Related research
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Mapping Kidney Damage in Acute and Chronic Kidney Disease
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Investigating kidney injury in children with chronic kidney disease
This study is looking at how to help kids with chronic kidney disease avoid sudden kidney problems and stay healthy by finding out what factors can be changed and how these issues affect their kidneys over time.
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Investigating how heme affects kidney health in older adults
This study is looking at how certain old cells in the kidneys can cause problems in older adults with kidney issues, and it’s exploring whether a substance called heme might be making things worse; the goal is to find new ways to help improve kidney health in people aged 65 and older.
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Understanding kidney injury and disease using advanced imaging techniques
This study is looking at how kidney injuries and diseases affect your kidneys by examining tiny samples from patients who choose to join, using a special imaging technique to create detailed maps of kidney cells, which will help us better understand these conditions and find better treatments for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.