Cystatin C for early detection of contrast-induced acute kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll adult inpatients with chronic kidney disease who are scheduled for contrast-enhanced CT imaging or coronary angiography at three BayCare hospitals in Florida. Blood samples will be collected before and after contrast exposure to measure serum cystatin C and creatinine and to calculate cystatin C–based and creatinine-based GFR estimates. The timing and magnitude of changes in cystatin C versus creatinine will be compared, and analyses will examine how patient characteristics influence cystatin C–based GFR estimation. Clinicians will manage care per usual practice while researchers collect and analyze laboratory and clinical data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects ages 18 years and above
* Inpatients with CKD (Figure 1)
* Order for CT imaging study or coronary angiography with isohexol Omnipaque) contrast media.
* Pre and post contrast available
* All races and ethnicity of patients are eligible. We expect to analyze approximately equal number of men and women in this study.

Exclusion Criteria:

* Preexisting dialysis
* Patients under the age of 18 years
* Pregnancy
* Incarcerated individuals
* Patients with impaired cognition and unable to follow consent procedures
* Recent exposure to CM (within 2 days before/after procedure)
* Cardiac shock
* Medications that affect biomarkers, including corticosteroids, lfamethoxazoletrimethoprim

Where it's running

• Morton Plant Hospital
  Clearwater, Florida, United States Recruiting
• Morton Plant North Bay Hospital
  New Port Richey, Florida, United States Recruiting
• Mease Countryside Hospital
  Safety Harbor, Florida, United States Recruiting
• St. Anthony's Hospital
  St. Petersburg, Florida, United States Recruiting

Study contacts

• Study coordinator: Tracy Johns, PharmD
• Email: tracy.johns@baycare.org
• Phone: 727-519-1310

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.