Goal-directed blood pressure, fluid, and urine management to prevent kidney injury after kidney removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients undergoing unilateral radical nephrectomy or nephroureterectomy are randomized to a goal-directed intraoperative hemodynamic protocol or routine care. The intervention combines guided hydration, inotropic support, and forced diuresis to maintain pulse pressure variation <9%, mean arterial pressure ≥85 mmHg, and urine flow >200 ml/h (≈3 ml/kg/h). The trial measures the incidence of acute kidney injury after surgery and tracks longer-term renal function outcomes. Results will determine whether protocolized hemodynamic control reduces postoperative AKI and subsequent chronic kidney disease risk compared with standard management.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Age of 18 years or older;
2. Scheduled to undergo unilateral radical nephrectomy for renal cancer or unilateral radical nephroureterectomy for upper tract urothelial carcinoma.

Exclusion criteria

1. Diagnosed with chronic kidney disease stage 4 or stage 5 (GFR\<30 ml/min/1.73m2) before surgery;
2. Uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);
3. Combined with cardiovascular diseases with Revised Cardiac Risk Index (RCRI) \>1 or metabolic equivalents (METs) \<4;
4. Unable to communicate due to severe dementia, language barrier, or end-stage disease before surgery;
5. Other conditions that are considered unsuitable for inclusion (specific reasons should be indicated).

Where it's running

• Beijing University First Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
• Study coordinator: Dong-Xin Wang, MD,PhD
• Email: wangdongxin@hotmail.com
• Phone: 86 10 83572784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.