Evaluating kidney and blood pressure outcomes in childhood cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on childhood cancer survivors (CCS) who are at increased risk for chronic kidney disease (CKD) and hypertension (HTN) due to their cancer treatments. It aims to determine the prevalence of CKD and HTN at 3 and 5 years post-therapy, while also assessing the progression of kidney function and blood pressure over this period. The study will involve 500 CCS who received high-risk therapies and will analyze the relationship between acute kidney injury during treatment and subsequent cardiovascular risks. The findings will help refine guidelines for monitoring and managing kidney and blood pressure health in CCS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 3 years ± 6 months after therapy for first cancer
* Received high-risk therapy for first cancer, as defined by the Canadian Oncology Group (COG) as alkylating agents; platinums; abdominal or total body radiation; high dose methotrexate; stem cell transplant; nephrectomy; or other therapy which may be known to possibly cause late kidney and/or BP effects.

Exclusion Criteria:

* Pre-cancer severe CKD and/or previous kidney transplant
* \>19 years old at 3 years after cancer therapy completion

Where it's running

• The Hospital For Sick Children
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Michael Zappitelli, MD
• Email: michael.zappitelli@sickkids.ca
• Phone: 4168137605

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.