Using kidney Doppler and urine oxygen to predict acute kidney injury after open heart surgery
Official title: The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery
Run by Tanta University · NCT07037485 · Data updated 2026-11-12
This tests whether kidney Doppler measurements and urine oxygen levels can predict acute kidney injury in adults having elective on-pump open heart surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | September 1, 2026 |
| Study ends | September 1, 2026 |
| Registry record updated | June 25, 2025 |
| Trial ID | NCT07037485 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults older than 21 undergoing elective on-pump cardiac surgery who do not have chronic kidney disease, renal anatomical abnormalities, or current renal replacement therapy.
✕Probably not a fit
Patients with pre-existing chronic kidney disease, known renal structural abnormalities, those already on dialysis, or those undergoing emergency or off-pump procedures are unlikely to be eligible or to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in about 15–30% of patients after open heart procedures and is linked to higher morbidity, mortality, and longer hospital stays. This observational cohort will record renal resistive index (RRI) and renal artery pulsatility index (RAPI) by Doppler ultrasound alongside urinary oxygen partial pressure before, during, and after elective on-pump cardiac surgery. Investigators will correlate those measurements with postoperative development of AKI to determine their predictive value. The aim is to see if these noninvasive bedside measures can identify patients at imminent risk of kidney injury.
Why it matters
Potential benefit: If successful, these measures could help clinicians identify patients at higher risk for AKI after cardiac surgery earlier and enable steps to prevent or lessen kidney damage.
How similar studies have gone: Prior studies have reported that Doppler-derived RRI and RAPI can predict AKI risk and that urinary bladder oxygen falls with reduced renal perfusion, but combining these measures for CSA-AKI prediction is less well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age above 21 years. * Both sexes. * Undergoing elective on-pump cardiac surgery. Exclusion Criteria: * Patients with chronic kidney disease. * Patients with any renal pathology or anatomic kidney abnormalities. * Patients on renal replacement therapy.
Where it's running
-
Tanta University
Tanta, El-Gharbia, Egypt Recruiting
Study contacts
- Study coordinator: Amany M Badr, Master
- Email: amany.badr@med.tanta.edu.eg
- Phone: 00201018038038
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.