Clinical trial Recruiting at 1 site Observational Ages 21 and up

Using kidney Doppler and urine oxygen to predict acute kidney injury after open heart surgery

Official title: The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery

Run by Tanta University · NCT07037485 · Data updated 2026-11-12

This tests whether kidney Doppler measurements and urine oxygen levels can predict acute kidney injury in adults having elective on-pump open heart surgery.

More Acute Kidney Injury trials

Quick facts

Study typeObservational
Ages21 Years and up
SexAll
Enrollment50 (estimated)
SponsorTanta University
Academic / other
Locations1 site (Tanta, El-Gharbia)
StatusRecruiting
StartedOctober 1, 2024
Main results expectedSeptember 1, 2026
Study endsSeptember 1, 2026
Registry record updatedJune 25, 2025
Trial IDNCT07037485 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults older than 21 undergoing elective on-pump cardiac surgery who do not have chronic kidney disease, renal anatomical abnormalities, or current renal replacement therapy.

Probably not a fit

Patients with pre-existing chronic kidney disease, known renal structural abnormalities, those already on dialysis, or those undergoing emergency or off-pump procedures are unlikely to be eligible or to benefit from the findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in about 15–30% of patients after open heart procedures and is linked to higher morbidity, mortality, and longer hospital stays. This observational cohort will record renal resistive index (RRI) and renal artery pulsatility index (RAPI) by Doppler ultrasound alongside urinary oxygen partial pressure before, during, and after elective on-pump cardiac surgery. Investigators will correlate those measurements with postoperative development of AKI to determine their predictive value. The aim is to see if these noninvasive bedside measures can identify patients at imminent risk of kidney injury.

Why it matters

Potential benefit: If successful, these measures could help clinicians identify patients at higher risk for AKI after cardiac surgery earlier and enable steps to prevent or lessen kidney damage.

How similar studies have gone: Prior studies have reported that Doppler-derived RRI and RAPI can predict AKI risk and that urinary bladder oxygen falls with reduced renal perfusion, but combining these measures for CSA-AKI prediction is less well established.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age above 21 years.
* Both sexes.
* Undergoing elective on-pump cardiac surgery.

Exclusion Criteria:

* Patients with chronic kidney disease.
* Patients with any renal pathology or anatomic kidney abnormalities.
* Patients on renal replacement therapy.

Where it's running

  • Tanta University
    Tanta, El-Gharbia, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.