Using kidney Doppler and urine oxygen to predict acute kidney injury after open heart surgery
The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery
This tests whether kidney Doppler measurements and urine oxygen levels can predict acute kidney injury in adults having elective on-pump open heart surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Trial ID | NCT07037485 on ClinicalTrials.gov |
What this trial studies
Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in about 15–30% of patients after open heart procedures and is linked to higher morbidity, mortality, and longer hospital stays. This observational cohort will record renal resistive index (RRI) and renal artery pulsatility index (RAPI) by Doppler ultrasound alongside urinary oxygen partial pressure before, during, and after elective on-pump cardiac surgery. Investigators will correlate those measurements with postoperative development of AKI to determine their predictive value. The aim is to see if these noninvasive bedside measures can identify patients at imminent risk of kidney injury.
Who should consider this trial
Good fit: Adults older than 21 undergoing elective on-pump cardiac surgery who do not have chronic kidney disease, renal anatomical abnormalities, or current renal replacement therapy.
Not a fit: Patients with pre-existing chronic kidney disease, known renal structural abnormalities, those already on dialysis, or those undergoing emergency or off-pump procedures are unlikely to be eligible or to benefit from the findings.
Why it matters
Potential benefit: If successful, these measures could help clinicians identify patients at higher risk for AKI after cardiac surgery earlier and enable steps to prevent or lessen kidney damage.
How similar studies have performed: Prior studies have reported that Doppler-derived RRI and RAPI can predict AKI risk and that urinary bladder oxygen falls with reduced renal perfusion, but combining these measures for CSA-AKI prediction is less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age above 21 years. * Both sexes. * Undergoing elective on-pump cardiac surgery. Exclusion Criteria: * Patients with chronic kidney disease. * Patients with any renal pathology or anatomic kidney abnormalities. * Patients on renal replacement therapy.
Where this trial is running
Tanta, El-Gharbia
- Tanta University — Tanta, El-Gharbia, Egypt (Recruiting)
Study contacts
- Study coordinator: Amany M Badr, Master
- Email: amany.badr@med.tanta.edu.eg
- Phone: 00201018038038
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.