Better follow-up and testing after acute kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The work has three linked parts: a biochemical comparison of creatinine, cystatin C and iohexol renal clearance to determine the most reliable measure of kidney function after AKI; structured questionnaires and semi‑structured interviews to document patients' symptoms and experiences; and participatory workshops to develop practical follow‑up and support recommendations. Adults who had AKI in hospital are invited to attend around 60–90 days after their peak creatinine for blood tests, body composition measurements, questionnaires, or interviews as appropriate. The study excludes people on dialysis, with a renal transplant, pregnant or breastfeeding, or unable to give consent. Findings will be used to propose clearer testing protocols and patient-centred support plans for post‑AKI care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Observational study workstream

* Age 18-85 years
* AKI stage 2 or 3 during hospital admission OR AKI stage 1 of at least 7 days duration during hospital admission
* 60-90 days after peak creatinine Qualitative interview workstream
* Age 18-85 years
* AKI during hospital admission
* 60-90 days after peak creatinine Participatory workshop workstream
* Age 18-85 years
* Relevant experience (as assessed by the investigator) which could include personal experience of an episode of hospitalised AKI as a patient of carer, experience of managing AKI or related problems in a professional capacity or knowledge of a particular community.

Exclusion Criteria:

Observational study workstream

* Inability to give informed consent
* No baseline creatinine available in previous 12 months
* Pregnancy or breastfeeding
* Current treatment with dialysis
* Renal transplant
* Pacemaker in situ
* Previous amputation
* Allergy to Omnipaque contrast agent (WP1 only)
* Manifest thyrotoxicosis (WP1 only)
* Ascites or significant (grade 3 to 4) peripheral oedema, defined as ≥6 mm pit, lasting for \>1 minute after 5-second compression over tibia or medial malleolus (WP1 only) Qualitative interview workstream
* Inability to give informed consent
* No baseline creatinine available in previous 12 months
* Current treatment with dialysis
* Renal transplant
* Receiving palliative care Participatory workshop workstream
* Inability to give informed consent
* Inability to communicate in English (the qualitative workshops will be held in English)

Where it's running

• University Hospitals of Derby and Burton NHS Foundation Trust
  Derby, Derbyshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Nicholas Selby — University of Nottingham
• Study coordinator: Kerry Horne Dr, BMBCh
• Email: kerry.horne@nottingham.ac.uk
• Phone: +44 01332 788262

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.