Biomarkers to predict CSA-AKI risk before heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses nested case-control analyses within prospective cohorts of adults scheduled for cardiovascular surgery. It collects blood, urine, stool samples and clinical data before and after contrast exposure and around the surgical procedure, tracking CSA-AKI occurrence and outcomes over time. Biomarkers are discovered and validated with multi-omics and machine learning approaches to see if they can predict CSA-AKI before it develops. The study aims to identify reliable biomarker signatures that improve early risk stratification in this patient group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Age no less than 18 years old;
* 2\. Scheduled cardiovascular surgery is proposed;
* 3\. Pre-angiography and preoperative serum creatinine \<354 μ mol/L;
* 4\. Informed consent.

Exclusion Criteria:

* 1\. Women who have a pregnancy plan within one year, are pregnant, or are breastfeeding;
* 2\. Patients who have severe side effects such as allergies to iodine contrast agents;
* 3\. Patients with hyperthyroidism;
* 4\. Those who had AKI before the contrast agent or within 2 weeks before the operation, or whose AKI has not been relieved after the operation;
* 5\. Patients undergoing kidney transplantation, peritoneal dialysis, or hemodialysis treatment;
* 6\. Patients with malignant tumors or those with an expected lifespan of less than 12 months;
* 7\. Angiography or preoperative acute heart failure;
* 8\. Patients who have a history of massive hemorrhage in the past 30 days or have contraindications to anticoagulant therapy.

Where it's running

• Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Cardiovascular Diseases
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Jianfang Cai
• Email: caijfbj@126.com
• Phone: +86 15801601007

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.