A large biobank for acute and emergency medicine
Acutelines: a Large Biobank Aiming to Improve Early Recognition of Acute Diseases, Contribute to the Development of Personalized Medicine and Optimize Short- and Long-term Outcome
University Medical Center Groningen · NCT04615065
This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 35000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Medical Center Groningen (other) |
| Locations | 1 site (Groningen) |
| Trial ID | NCT04615065 on ClinicalTrials.gov |
What this trial studies
Acutelines is a prospective biobank designed to collect extensive data and biomaterials from patients presenting with a variety of acute conditions at the Emergency Department. The initiative aims to enhance the understanding of acute diseases and improve treatment outcomes through interdisciplinary research. By systematically gathering clinical data, imaging, and biomaterials over time, the project seeks to develop personalized treatment strategies and predict patient outcomes more effectively. The study employs a deferred consent procedure to facilitate data collection while ensuring patient rights are respected.
Who should consider this trial
Good fit: Ideal candidates for this study include patients triaged as red or orange in the Manchester triage system, or those with specific acute conditions such as sepsis or acute kidney injury.
Not a fit: Patients referred for organ transplantation or those transferred from other hospitals may not benefit from this study.
Why it matters
Potential benefit: If successful, this biobank could lead to improved recognition and treatment of acute diseases, ultimately enhancing patient outcomes.
How similar studies have performed: Other studies utilizing biobanks for acute conditions have shown promise, but this specific approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria, at least one of the following: * Triaged as one of highest two triage categories (red or orange) according to the Manchester triage system; * Triaged as the third highest triage category (yellow) and arrival by EMS of Helicopter Emergency Medical Service (HEMS; * Shock * Suspicion of sepsis (based on either physicians' suspicion, Sepsis-2 or Sepsis-3 criteria) * Acute kidney injury (AKI) * Anaphylactic reaction * Syncope * Intoxication * Thrombosis * Pulmonary embolism * Bleeding while using anti-coagulant drugs * Gastro-intestinal bleeding * Electrolyte disturbance Exclusion Criteria: * Referred for organ transplantation as recipient * Transfer from other hospital * Accidental contact patient material (i.e. internal work-related accident) While data- and imaging will be collected from all these patients, biomaterials will only be collected from patients fulfilling the first criterion (i.e. triaged as one of highest two triage categories \[red or orange\] according to the Manchester triage system) and from patients with shock or a suspicion of sepsis.
Where this trial is running
Groningen
- University Medical Center Groningen — Groningen, Netherlands (RECRUITING)
Study contacts
- Study coordinator: Hjalmar Bouma, MD, PhD
- Email: acutelines@umcg.nl
- Phone: +31 50 361 6161
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Disease, Sepsis, Pneumonia, Frailty, Complication of Treatment, Pulmonary Embolism, Thrombosis, Acute Kidney Injury