New kidney biomarkers to predict kidney injury after radical nephrectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll adults undergoing unilateral radical nephrectomy at Peking University First Hospital and collect perioperative blood and urine samples to measure novel renal injury, stress, and functional biomarkers. Researchers will use standard KDIGO criteria (serum creatinine and urine output) as the clinical reference and compare how well the novel biomarkers predict postoperative acute kidney injury. Participants will be followed for one year to determine whether early biomarker changes predict longer-term chronic kidney disease. The goal is to define which perioperative biomarker patterns offer added predictive value beyond traditional measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years;
* Scheduled to undergo unilateral radical nephrectomy.

Exclusion Criteria:

* Solitary kidney;
* Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR \<30 mL/min/1.73m²);
* Tumor invasion of the vena cava requiring thrombectomy;
* Other conditions deemed by the investigator as unsuitable for participation in this study.

Where it's running

• Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Qiongfang Wu, MD
• Email: wuqf91@163.com
• Phone: 8610 83572460

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Goal-directed blood pressure, fluid, and urine management to prevent kidney injury after kidney removal

  This will try a targeted plan of fluids, medicines, and forced urine output during surgery to see if it reduces acute kidney injury in adults having a radical nephrectomy or nephroureterectomy.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT05149196

• Recovery, quality of life, and physical function after partial or radical nephrectomy

  This study tests recovery, quality of life, and physical function before and after nephrectomy to see how patients fare depending on the surgery type.

  Recruiting Herlev and Gentofte Hospital · Herlev · NCT07908277

• Pain management plan implementation for major open abdominal surgeries

  This trial tests an opioid-epidural pain management approach to see if it improves post-surgical pain control for adults undergoing open abdominal procedures like colectomy, hepatectomy, and nephrectomy.

  Recruiting National and Kapodistrian University of Athens · Athens, Athens · NCT07901582

• Remote Ischemic Preconditioning at Different Times After Heart Valve Surgery

  This study tests whether applying brief, controlled blood-flow restrictions to a limb at different times after heart valve surgery can help protect organs and reduce complications like kidney injury.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07888634

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Biomarkers to predict CSA-AKI risk before heart surgery

  This study tests new biomarkers to see if they can predict CSA-AKI risk in adults undergoing cardiovascular surgery.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07811570

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.