Remote Ischemic Preconditioning at Different Times After Heart Valve Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients undergoing elective heart valve surgery with cardiopulmonary bypass will receive remote ischemic preconditioning at varying time points after surgery to see if it reduces organ injury. The approach is non-pharmacological and designed to be simple to implement in clinical settings. The trial assesses safety and potential protective effects on organs, particularly the kidneys, by comparing outcomes across timing groups. The intervention is delivered in a standardized nursing protocol at the bedside. The study is conducted at Fujian Medical University Union Hospital in Fuzhou, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged ≥18 years who are scheduled for elective CPB mitral and/or aortic valve surgery

Exclusion Criteria:

* Diagnosed with end-stage renal disease, chronic kidney disease stage 4-5, or have been receiving long-term renal replacement therapy
* Preoperative renal function impairment (eGFR \< 30 ml·min-¹·1.73 m-²)
* Severe peripheral vascular disease, thrombosis, etc.
* History of mental illness or mild cognitive impairment (using Mini-Cog screening, score \< 3)
* Combined surgical procedures (such as coronary artery bypass grafting, aortic dissection repair, and ascending aortic reconstruction) were excluded to minimize the potential impact of variations in surgical complexity on the risk of complications and the outcomes of the intervention
* Diagnosed with myocardial infarction, systemic infection, or sepsis within 7 days
* Participated in other clinical studies

Where it's running

• Fujian Medical University Union Hospital, Fujian, Fuzhou 350000
  Fuzhou, Fujian, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.