Biomarkers to identify kidney injury sub-types in sepsis patients
Official title: Identification and Validation of Biological Sub-phenotypes of Sepsis-induced Acute Kidney Injury: A Precision Medicine Approach to Improve Clinical Outcomes
Funded at University of Washington · NIH-11369266 · Data updated 2026-11-12
This grant tests whether two distinct kidney injury sub-types in sepsis can be found early in emergency care and used to guide better treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $582,872 |
| NIH project number | 5R01DK133177-05 |
| Project ID | NIH-11369266 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sepsis-associated acute kidney injury presenting to the emergency department or admitted to hospital.
✕Less likely to help
Patients without sepsis or without AKI may not benefit from this specific sub-phenotype approach.
What this research studies
In this project, researchers aim to identify specific biomarker patterns that separate sub-phenotypes of sepsis-related kidney injury in patients who come to the ER. They will expand their biomarker panel and test its ability to classify patients quickly, so clinicians can tailor therapies such as vasopressin to the right subgroup. The work builds on prior findings showing different risks and responses to treatment between sub-phenotypes and aims to bring these insights into bedside decision-making. The study involves analyzing patient samples and clinical data collected during emergency department encounters and subsequent hospital care.
Why it matters
Potential benefit: If successful, the findings could lead to faster, more personalized treatments for sepsis-induced AKI and better outcomes for patients.
How similar studies have gone: Previous work has demonstrated reproducible AKI sub-phenotypes and biomarker models by independent groups.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Bhatraju, Pavan Kumar — University of Washington
- Study coordinator: Bhatraju, Pavan Kumar
Related research
Other NIH-funded projects on the same topics.
-
Understanding Different Types of Kidney Injury in Sepsis to Improve Care
This work aims to find specific types of acute kidney injury in patients with sepsis to help doctors provide more personalized and effective treatments.
-
Understanding the Gut Microbiome in Sepsis-Related Kidney Injury
This research explores how the bacteria in your gut might influence why some people with severe infections develop kidney damage.
-
Diagnosing and staging kidney injury related to sepsis
This study is looking to find new ways to quickly and accurately diagnose kidney damage in people with sepsis by testing blood samples from mice, which could lead to a simple blood test for doctors to use in treating patients.
-
Investigating the gut microbiome's role in kidney injury during sepsis
This study is looking at how the bacteria in your gut might affect kidney problems in people with sepsis, and it aims to find out which specific bacteria could help predict how serious those kidney issues might be.
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Identifying different types of kidney injury caused by sepsis to improve treatment outcomes.
This study is looking at how different types of kidney problems caused by sepsis can be treated better by using specific tests to find out what each patient needs, so that doctors can give the best care right away in emergency rooms.
-
Identifying unique subtypes of kidney injury in children with sepsis
This study is looking at children with septic shock and kidney problems to find better ways to treat them by understanding the different types of their condition, so we can choose the right medicines to help them feel better.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.