Measuring kidney blood flow changes in critically ill patients on dialysis.
Changes of Renal Resistive Index in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy - Observational Study.
This study is testing if measuring kidney blood flow changes can help doctors spot kidney problems earlier in critically ill patients on dialysis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Uniwersytecki Szpital Kliniczny w Opolu Academic / other |
| Locations | 1 site (Opole, Opole Voivodeship) |
| Trial ID | NCT06174610 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between changes in the renal resistive index (RRI) and the recovery of kidney function in critically ill patients undergoing continuous renal replacement therapy (CRRT) for acute kidney injury (AKI). By utilizing Doppler ultrasound measurements to assess RRI, the study seeks to identify earlier indicators of kidney dysfunction compared to traditional markers like serum creatinine. The findings could enhance monitoring strategies for AKI in intensive care settings, potentially improving patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are ICU patients who are undergoing continuous renal replacement therapy due to acute kidney injury.
Not a fit: Patients under 18 years old, pregnant women, or those with severe chronic kidney disease or other specific conditions that hinder reliable RRI measurement will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and intervention for acute kidney injury, improving recovery rates in critically ill patients.
How similar studies have performed: Previous studies have shown a correlation between renal resistive index and acute kidney injury, suggesting that this approach may be promising but is still being explored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All ICU patients undergoing CRRT due to AKI Exclusion Criteria: * age \<18 years * pregnancy * history of chronic kidney disease in stage 4 or 5 * post-kidney transplant status * mechanical circulatory support * occurrence of one or more conditions preventing reliable RRI measurement in both kidneys: * challenging technical conditions of ultrasound examination, hindering proper visualization of the kidney * post-kidney injury in grade III and higher, according to AAST * advanced parenchymal kidney pathology: atrophy, hypoplasia, cirrhosis, extensive ischemia (more than 2/3 of the parenchyma), * kidney diseases preventing parenchyma identification: advanced cancer (stage above T1 according to TNM), certain forms of polycystic kidney disease * inflammatory kidney diseases * obstructive uropathy * renal vascular pathologies: renal vein thrombosis, significant stenosis (\>60%), and renal artery occlusion.
Where this trial is running
Opole, Opole Voivodeship
- Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu — Opole, Opole Voivodeship, Poland (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.