Investigating the impact of a toxin on heart and blood vessel function during acute kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the relationship between the accumulation of the uremic toxin Indoxyl Sulfate and cardiovascular complications in patients experiencing acute kidney injury (AKI). It focuses on patients hospitalized with moderate to severe AKI, assessing how high levels of this toxin may lead to early vascular and cardiac dysfunction, measured through pulse wave velocity. By analyzing blood samples, the study seeks to uncover the mechanisms linking AKI and cardiovascular risks, which remain poorly understood despite existing associations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18 years old.
* Patients hospitalized in conventional hospital departments and in intensive care units of nephrology.
* Patients with moderate to severe AKI (KDIGO 2 or 3) without dialysis.
* AKI from functional or organic aetiology

Exclusion Criteria:

* Patients with severe CKD (GFR\<45ml/min/1.73 m2) or with kidney transplants.
* Patients with AKI from septic or obstructive aetiology.
* Patients with AKI from toxic aetiology whose toxic would be also responsable of cardia toxicity.
* Patients with sepsis or blood inflammation.
* Patients with severe chronic cardia dysfunction.
* Patients with arrhythmia or complete heart block.
* Patients with peripheral artery occlusive disease.
* Pregnancy.
* Patients on palliative care.

Where it's running

• Amiens hospital
  Amiens, France Recruiting

Study contacts

• Study coordinator: Pauline Caillard, MD
• Email: caillard.pauline@chu-amiens.fr
• Phone: 03 22 45 58 66

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hemoadsorption with the Jafron HA130 cartridge during hemodialysis for adults on maintenance dialysis with inflammation

  This trial will try adding Jafron HA130 hemoadsorption to regular hemodialysis to see if it reduces inflammation in adults on maintenance dialysis who have high CRP or IL-6.

  Recruiting Botkin Hospital · Moscow · NCT07123909

• Remote Ischemic Preconditioning at Different Times After Heart Valve Surgery

  This study tests whether applying brief, controlled blood-flow restrictions to a limb at different times after heart valve surgery can help protect organs and reduce complications like kidney injury.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07888634

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Heat therapy during reduced activity to protect heart and muscle health

  A randomized trial tests whether daily Finnish dry sauna help preserves cardiovascular and muscle health when daily activity is reduced for seven days in healthy adults.

  Recruiting Brigham Young University · Provo, Utah · NCT07847424

• Biomarkers to predict CSA-AKI risk before heart surgery

  This study tests new biomarkers to see if they can predict CSA-AKI risk in adults undergoing cardiovascular surgery.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07811570

• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

  This trial tests whether using the oXiris hemofilter during continuous kidney replacement helps lower endotoxin levels in adults with septic shock who need CRRT.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07807410

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.