Using furosemide to assess kidney recovery in critically ill patients on dialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial compares the effectiveness of a furosemide stress test (FST) against standard care in evaluating renal recovery in critically ill patients undergoing continuous renal replacement therapy (CRRT) for acute kidney injury. The study aims to determine if the FST can provide better insights into kidney function recovery compared to traditional methods. Participants will be adults with stage 3 acute kidney injury who have been on CRRT for at least 48 hours. The trial seeks to address the lack of evidence regarding the timing of withholding CRRT and its associated complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult 18 year of age or older
* Acute kidney injury (AKI) stage 3 according to Kidney Disease Improving Global Outcomes (KDIGO) classification with oliguria (urine \<400 ml/day)
* Initiate CRRT in ICU (medical ICU, surgical ICU, cardiac care unit) for at least 48 hours (time for initiation and modality of CRRT can adjust by clinician)

Exclusion Criteria:

* Use any inotropic drug (norepinephrine, epinephrine, dopamine, dobutamine)
* Serum K \<3.5 or \>5 mmol/L
* Arterial potential of Hydrogen (pH) \<7.3
* Serum bicarbonate (HCO3) \<15 mmol/L
* Urine volume ≥2,300 mL/day
* Previous chronic kidney disease (CKD) stage 5 or estimated glomerular filtration rate (eGFR) \<15 mL/min/1.73 m2
* Previous RRT within 14 days
* Kidney transplantation
* Obstructive etiology for AKI
* Toxin/drug that necessitates RRT
* Allergy to furosemide
* Moribund with expected death within 24 hours
* Pregnancy

Where it's running

• Chiang Mai University
  Chiang Mai, Thailand Recruiting

Study contacts

• Study coordinator: Prit Kusirisin, MD
• Email: jingprit@hotmail.com
• Phone: +66897574028

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.