Comparing two methods of renal replacement therapy for patients on ECMO

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of two different methods for administering renal replacement therapy (RRT) in patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO). The two methods being compared are an integrated connection, where the RRT machine is directly incorporated into the ECMO circuit, and a parallel connection, which uses a separate vascular access. The goal is to determine which method may reduce complications such as infections and bleeding, which are critical concerns for patients on ECMO. The study aims to provide evidence-based recommendations for RRT in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged above 18 years
* Patient on VA-ECMO who requires the initiation of continuous RRT during VA-ECMO treatment
* Patient with a foreseeable length of stay in intensive care greater than 24 hours

Exclusion Criteria:

* Patient who does not have a vascular capital allowing for the insertion of a new dialysis catheter to administer RRT and therefore cannot be randomized to the parallel connection group
* High pressures monitored on ECMO not allowing direct RRT catherter on ECMO
* Pregnant, parturient, or breastfeeding women
* Patient deprived of liberty by a judicial or administrative decision
* Patient under psychiatric care
* Patient subject to a legal protection measure (guardianship, curators)
* Patient not affiliated to a social security system
* Patient participating in another interventional research study in the field of extra purification renal

Where it's running

• CHU de Bordeaux, GH Sud, Service d'anesthésie-réanimation cardiovasculaire, Hôpital cardiologique
  Bordeaux, France Recruiting
• CHU de Clermont Ferrand, Pôle de médecine péri-opératoire/Chirurgie cardiaque, Hôpital Gabriel Montpied
  Clermont-Ferrand, France Recruiting
• Centre Hospitalo Universitaire de Dijon, Unité Réanimation Cardio-Vasculaire,
  Dijon, France Recruiting
• CHU de Grenoble, Service de réanimation cardiovasculaire et thoracique, Pôle anesthésie réanimation, Hôpital Nord
  Grenoble, France Recruiting
• Hospices Civils de Lyon, Service d'Anesthésie-Réanimation cardiovasculaire, Hôpital Louis Pradel
  Lyon, France Recruiting
• CHU de Montpellier, Département d'anesthésie-réanimation, Pôle Cœur-poumons, Hôpital Arnaud de Villeneuve
  Montpellier, France Recruiting

Study contacts

• Study coordinator: Frank BIDAR, MD
• Email: frank.bidar@chu-lyon.fr
• Phone: (33) 472 116 942

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.