Using ultrasound to prevent and treat kidney injury after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine if ultrasound evaluation of venous congestion in the liver and kidneys can guide treatment to prevent and manage acute kidney injury (AKI) following cardiac surgery. Participants will either receive the ultrasound-guided treatment or a placebo, with fluid management based on the Venous Excess Ultrasound Score (VEXUS). Kidney function will be monitored daily for seven days post-surgery, and data will be collected for statistical analysis to assess the effectiveness of this approach compared to standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients in the Cardiac Surgery ICU who develop acute kidney injury according to KDIGO criteria, within 48 hours of ICU admission after cardiac surgery
* Elective and non-elective cardiac surgery.

Exclusion Criteria:

* Patient refusal
* Severe chronic renal failure (GFR\<15 mL/min/m2 or on hemodialysis).
* Critical preoperative condition (severe cardiogenic shock, resuscitated cardiac arrest, support with mechanical circulatory assist devices).
* Liver cirrhosis or inferior vena cava obstruction.
* Pregnancy.
* Morbid obesity (BMI\>40 kg/m2).
* Delirium or other condition that prevents the performance of an ultrasound study.

Where it's running

• Onassis Cardiac Surgery Center
  Athens, Kallithea, Greece Recruiting

Study contacts

• Study coordinator: Stavros Dimopoulos, PhD, EDIC
• Email: stdimop@gmail.com
• Phone: 00306973956974

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.