Sudden (acute) kidney injury in children with chronic kidney disease
Official title: Acute Kidney Injury in Children with Chronic Kidney Disease
Funded at Yale University · NIH-11319873 · Data updated 2026-11-12
This project looks at what leads to sudden kidney injury in children who already have chronic kidney disease so doctors can better prevent and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 5, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2026 |
| Award (this year) | $334,046 |
| NIH project number | 5R01DK135650-04 |
| Project ID | NIH-11319873 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with chronic kidney disease, especially those enrolled in or eligible for the CKiD cohort at participating pediatric nephrology centers, are the ideal candidates.
✕Less likely to help
People without chronic kidney disease or those not followed at participating CKiD centers are unlikely to be included or to receive direct benefits from this study.
What this research studies
You or your child would be followed through the large CKiD study, which includes about 1,100 children with chronic kidney disease. Each year you would have kidney function checks, blood pressure measurements, and urine tests for albumin to track changes over time. Researchers will also measure blood and urine biomarkers that reflect both glomerular and tubular kidney health to understand how and why acute injuries happen. By comparing kids who do and do not have episodes of acute kidney injury, the team hopes to identify modifiable risk factors and early biological signs that could signal higher risk.
Why it matters
Potential benefit: If successful, the work could help prevent acute kidney injury in children with CKD, slow disease progression, and lower the chance of needing dialysis or transplant.
How similar studies have gone: Earlier retrospective and smaller biomarker studies linked AKI to worse outcomes, but this large prospective pediatric cohort approach is relatively new and aims to provide stronger, more reliable evidence.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Greenberg, Jason Henry — Yale University
- Study coordinator: Greenberg, Jason Henry
Related research
Other NIH-funded projects on the same topics.
-
Illuminating human kidney injury with advanced tissue imaging
This grant helps researchers map kidney injury in people by using a powerful imaging technique on kidney biopsy tissue to reveal cellular details that could guide better treatments.
-
How free heme damages kidney cell mitochondria and drives sudden and chronic kidney injury
This project looks at whether excess heme causes mitochondrial damage and aging-like changes in kidney cells that contribute to sudden (acute) and long-term (chronic) kidney injury in people at risk.
-
Mapping Kidney Damage in Acute and Chronic Kidney Disease
This project uses advanced imaging to create detailed maps of kidney tissue from patients with acute and chronic kidney disease to better understand these conditions.
-
Investigating kidney injury in children with chronic kidney disease
This study is looking at how to help kids with chronic kidney disease avoid sudden kidney problems and stay healthy by finding out what factors can be changed and how these issues affect their kidneys over time.
-
Investigating how heme affects kidney health in older adults
This study is looking at how certain old cells in the kidneys can cause problems in older adults with kidney issues, and it’s exploring whether a substance called heme might be making things worse; the goal is to find new ways to help improve kidney health in people aged 65 and older.
-
Understanding kidney injury and disease using advanced imaging techniques
This study is looking at how kidney injuries and diseases affect your kidneys by examining tiny samples from patients who choose to join, using a special imaging technique to create detailed maps of kidney cells, which will help us better understand these conditions and find better treatments for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.