Sudden (acute) kidney injury in children with chronic kidney disease
Acute Kidney Injury in Children with Chronic Kidney Disease
This project looks at what leads to sudden kidney injury in children who already have chronic kidney disease so doctors can better prevent and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11319873 on NIH RePORTER |
What this research studies
You or your child would be followed through the large CKiD study, which includes about 1,100 children with chronic kidney disease. Each year you would have kidney function checks, blood pressure measurements, and urine tests for albumin to track changes over time. Researchers will also measure blood and urine biomarkers that reflect both glomerular and tubular kidney health to understand how and why acute injuries happen. By comparing kids who do and do not have episodes of acute kidney injury, the team hopes to identify modifiable risk factors and early biological signs that could signal higher risk.
Who could benefit from this research
Good fit: Children and adolescents with chronic kidney disease, especially those enrolled in or eligible for the CKiD cohort at participating pediatric nephrology centers, are the ideal candidates.
Not a fit: People without chronic kidney disease or those not followed at participating CKiD centers are unlikely to be included or to receive direct benefits from this study.
Why it matters
Potential benefit: If successful, the work could help prevent acute kidney injury in children with CKD, slow disease progression, and lower the chance of needing dialysis or transplant.
How similar studies have performed: Earlier retrospective and smaller biomarker studies linked AKI to worse outcomes, but this large prospective pediatric cohort approach is relatively new and aims to provide stronger, more reliable evidence.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Greenberg, Jason Henry — Yale University
- Study coordinator: Greenberg, Jason Henry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.