Ultra-low contrast coronary angiography for patients with acute kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an open-label, non-inferiority randomized controlled trial enrolling hospitalized adults with acute kidney injury who require invasive coronary angiography. Participants are randomized to immediate angiography (within 24 hours) or to delayed angiography after renal function stabilizes, with percutaneous coronary intervention deferred for 7 days if indicated. Ultra-low contrast techniques will be used during angiography, and serum creatinine will be measured at enrollment, within 6 hours before angiography, and at 24 hours, 48 hours, and 1 week afterward. Hydration and other peri-procedural care are managed by the treating team and the primary outcome compares kidney-related safety between the two timing strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospitalized patients who have AKI at admission or who develop AKI during admission and require invasive coronary angiography will be included in the trial.

Exclusion Criteria:

* Stabilized renal function manifested by unchanged or downtrending serum creatinine during a 24-hour period prior to enrollment.
* Contraindication for invasive coronary angiography other than AKI.
* Percutaneous coronary intervention is indicated and cannot be postponed by 7 days.
* Need for renal replacement therapy before coronary angiography or planned renal replacement therapy after coronary angiography (if premeditated before coronary angiography).
* Administration of intravascular contrast media during 7 days prior to the coronary angiography or within 6 days after coronary angiography.
* Pregnant patients, prisoners, cognitively impaired subjects, age below 18 years, unable or unwilling to provide informed consent.

Where it's running

• Tulane University Medical Center
  New Orleans, Louisiana, United States Recruiting
• University Medical Center
  New Orleans, Louisiana, United States Recruiting

Study contacts

• Principal investigator: Zach Rozenbaum, MD — Tulane University
• Study coordinator: Zach Rozenbaum, MD
• Email: zrozenbaum@tulane.edu
• Phone: 504-988-5493

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.