Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Using digital tools to improve care after acute kidney injury

Official title: UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events- A Pragmatic Randomized Controlled Trial in Connect Care

Run by University of Alberta · NCT05806645 · Data updated 2026-11-12

This study is testing a new way to improve care for patients recovering from acute kidney injury by creating personalized care plans that help them transition smoothly after leaving the hospital.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment6046 (estimated)
SponsorUniversity of Alberta
Academic / other
Locations2 sites (Calgary, Alberta and 1 other locations)
StatusRecruiting
StartedFebruary 12, 2025
Main results expectedSeptember 2028
Study endsSeptember 2029
Registry record updatedJune 10, 2026
Trial IDNCT05806645 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who have been hospitalized and diagnosed with acute kidney injury.

Probably not a fit

Patients with advanced chronic kidney disease, those on dialysis, or with certain other medical conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance post-discharge care for patients who have experienced acute kidney injury (AKI) by co-developing a personalized care plan based on individual risk factors. Utilizing Alberta's new electronic health record system, the study will identify hospitalized patients with AKI and implement a risk-guided transition of care intervention. The approach focuses on addressing gaps in communication, care coordination, and education to improve health outcomes and patient experiences. The study builds on previous pilot work that validated a risk prediction model for AKI survivors.

Why it matters

Potential benefit: If successful, this study could significantly reduce the risk of severe health complications following acute kidney injury.

How similar studies have gone: Previous studies have shown promise in using risk-guided strategies for AKI follow-up, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

(all of)

* Age ≥ 18 years old
* Hospitalized at site using AHS EHR
* Acute Kidney Injury (Stage 1-3) identified in hospital per KDIGO guideline criteria

Exclusion Criteria:

(any of)

* Pre-hospitalization advanced CKD: eGFR\<30 mL/min/1.73m2
* Pre-hospitalization dialysis
* Very low risk (\<1% risk) of advanced CKD
* Non-Alberta resident
* Palliative goals of care
* Enrolled in the UPTAKE VC Trial
* Admitted under a nephrologist at time of discharge
* Dialysis on at least 2 days in the last week prior to discharge
* Receiving apheresis
* Kidney transplant recipient
* Kidney transplant donor
* Diagnosis of Glomerulonephritis
* Cirrhosis AND complication of cirrhosis in medical history or active problem list (ascites, varices, hepatic encephalopathy, hepatorenal syndrome)

Where it's running

  • Foothills Medical Centre
    Calgary, Alberta, Canada
    Recruiting
  • University of Alberta Hospital
    Edmonton, Alberta, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.