Using digital tools to improve care after acute kidney injury
Official title: UPTAKE: Using Personalized Risk and Digital Tools to Guide Transitions Following Acute Kidney Events- A Pragmatic Randomized Controlled Trial in Connect Care
Run by University of Alberta · NCT05806645 · Data updated 2026-11-12
This study is testing a new way to improve care for patients recovering from acute kidney injury by creating personalized care plans that help them transition smoothly after leaving the hospital.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 6046 (estimated) |
| Sponsor | University of Alberta Academic / other |
| Locations | 2 sites (Calgary, Alberta and 1 other locations) |
| Status | Recruiting |
| Started | February 12, 2025 |
| Main results expected | September 2028 |
| Study ends | September 2029 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT05806645 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been hospitalized and diagnosed with acute kidney injury.
✕Probably not a fit
Patients with advanced chronic kidney disease, those on dialysis, or with certain other medical conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance post-discharge care for patients who have experienced acute kidney injury (AKI) by co-developing a personalized care plan based on individual risk factors. Utilizing Alberta's new electronic health record system, the study will identify hospitalized patients with AKI and implement a risk-guided transition of care intervention. The approach focuses on addressing gaps in communication, care coordination, and education to improve health outcomes and patient experiences. The study builds on previous pilot work that validated a risk prediction model for AKI survivors.
Why it matters
Potential benefit: If successful, this study could significantly reduce the risk of severe health complications following acute kidney injury.
How similar studies have gone: Previous studies have shown promise in using risk-guided strategies for AKI follow-up, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: (all of) * Age ≥ 18 years old * Hospitalized at site using AHS EHR * Acute Kidney Injury (Stage 1-3) identified in hospital per KDIGO guideline criteria Exclusion Criteria: (any of) * Pre-hospitalization advanced CKD: eGFR\<30 mL/min/1.73m2 * Pre-hospitalization dialysis * Very low risk (\<1% risk) of advanced CKD * Non-Alberta resident * Palliative goals of care * Enrolled in the UPTAKE VC Trial * Admitted under a nephrologist at time of discharge * Dialysis on at least 2 days in the last week prior to discharge * Receiving apheresis * Kidney transplant recipient * Kidney transplant donor * Diagnosis of Glomerulonephritis * Cirrhosis AND complication of cirrhosis in medical history or active problem list (ascites, varices, hepatic encephalopathy, hepatorenal syndrome)
Where it's running
-
Foothills Medical Centre
Calgary, Alberta, Canada Recruiting -
University of Alberta Hospital
Edmonton, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Neesh Pannu — University of Alberta
- Study coordinator: Neesh Pannu
- Email: npannu@ualberta.ca
- Phone: 780 492 8519
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.