Timing of kidney treatment in critically ill patients
Official title: Early vs Late CRRT, a Propensity Matched Multicenter Cohort Study
Run by Karolinska University Hospital · NCT03629977 · Data updated 2026-11-12
This study is trying to find out if starting kidney treatment earlier can help critically ill patients with kidney injury feel better and have better outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50000 (estimated) |
| Sponsor | Karolinska University Hospital Academic / other |
| Locations | 1 site (Stockholm) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | April 1, 2027 |
| Registry record updated | September 3, 2025 |
| Trial ID | NCT03629977 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are critically ill patients over 18 years of age admitted to intensive care units in Stockholm.
✕Probably not a fit
Patients under 18 years, those with do-not-attempt-resuscitation orders, or those expected to die within 12 hours of starting RRT may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the optimal timing for initiating renal replacement therapy (RRT) in critically ill patients suffering from acute kidney injury (AKI). Utilizing a large-scale intensive care database, the study aims to analyze data from over 60,000 patients across three hospitals in Stockholm. The researchers hypothesize that early initiation of RRT may lead to better patient outcomes, addressing a significant knowledge gap in current clinical practice. The study will also explore the variability in RRT timing and its impact on morbidity and mortality.
Why it matters
Potential benefit: If successful, this study could provide critical insights that improve treatment protocols for patients with acute kidney injury in intensive care settings.
How similar studies have gone: Previous studies have suggested benefits of early RRT, indicating that this approach may be promising, although conflicting results exist.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \*Critically ill patients admitted to intensive care units in Stockholm at: Karolinska University Hospital (Solna and Huddinge) and at Södersjukhuset. \*Patients over 18 years of age Exclusion Criteria: * Patients \<18 years * Patients with DNAR (do not attempt resuscitation)-orders * Patients dying within 12 hours of commencing renal replacement therapy.
Where it's running
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Karolinska University Hospital
Stockholm, Sweden Recruiting
Study contacts
- Principal investigator: Max Bell, MD, PhD — Karolinska Institutet
- Study coordinator: Max Bell, MD, PhD
- Email: max.bell@sll.se
- Phone: +46708278533
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Understanding how patients tolerate fluid removal during kidney support in the ICU
This observational study tests how well critically ill adults with acute kidney injury tolerate net fluid removal during continuous renal replacement therapy.
-
Choosing Wisely recommendations for care in the intensive care unit
This project will try the Choosing Wisely approach in adult ICU patients in Sweden to see if using fewer unnecessary tests and interventions is safe.
-
Sodium bicarbonate for critically ill patients with metabolic acidosis and AKI
This trial tests whether giving sodium bicarbonate helps reduce major kidney problems 90 days later in adults with septic or critical illness and kidney injury.
-
Epidemiology and care for dialysis in ICU patients with severe acute kidney injury in Latin America
This project will collect and compare data on adults in ICUs across Latin America who need dialysis for severe acute kidney injury to see how they are treated and what outcomes they have.
-
Comparing low and standard dose-intensity continuous renal replacement therapy in critically ill patients
This study is testing if a lower dose of kidney treatment is just as good as the standard dose for critically ill patients with acute kidney injury.
-
Using renal resistive index to predict acute kidney injury in high-risk patients
This study is testing if measuring kidney blood flow using ultrasound can help doctors spot acute kidney injury earlier in high-risk patients in the intensive care unit.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.