Clinical trial Recruiting at 1 site Observational Ages 18 and up

Timing of kidney treatment in critically ill patients

Official title: Early vs Late CRRT, a Propensity Matched Multicenter Cohort Study

Run by Karolinska University Hospital · NCT03629977 · Data updated 2026-11-12

This study is trying to find out if starting kidney treatment earlier can help critically ill patients with kidney injury feel better and have better outcomes.

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Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment50000 (estimated)
SponsorKarolinska University Hospital
Academic / other
Locations1 site (Stockholm)
StatusRecruiting
StartedNovember 1, 2025
Main results expectedDecember 31, 2026
Study endsApril 1, 2027
Registry record updatedSeptember 3, 2025
Trial IDNCT03629977 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are critically ill patients over 18 years of age admitted to intensive care units in Stockholm.

Probably not a fit

Patients under 18 years, those with do-not-attempt-resuscitation orders, or those expected to die within 12 hours of starting RRT may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the optimal timing for initiating renal replacement therapy (RRT) in critically ill patients suffering from acute kidney injury (AKI). Utilizing a large-scale intensive care database, the study aims to analyze data from over 60,000 patients across three hospitals in Stockholm. The researchers hypothesize that early initiation of RRT may lead to better patient outcomes, addressing a significant knowledge gap in current clinical practice. The study will also explore the variability in RRT timing and its impact on morbidity and mortality.

Why it matters

Potential benefit: If successful, this study could provide critical insights that improve treatment protocols for patients with acute kidney injury in intensive care settings.

How similar studies have gone: Previous studies have suggested benefits of early RRT, indicating that this approach may be promising, although conflicting results exist.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\*Critically ill patients admitted to intensive care units in Stockholm at: Karolinska University Hospital (Solna and Huddinge) and at Södersjukhuset.

\*Patients over 18 years of age

Exclusion Criteria:

* Patients \<18 years
* Patients with DNAR (do not attempt resuscitation)-orders
* Patients dying within 12 hours of commencing renal replacement therapy.

Where it's running

  • Karolinska University Hospital
    Stockholm, Sweden
    Recruiting

Study contacts

  • Principal investigator: Max Bell, MD, PhD — Karolinska Institutet
  • Study coordinator: Max Bell, MD, PhD
  • Email: max.bell@sll.se
  • Phone: +46708278533

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.