Investigating nephroprotective measures for critically ill patients with acute kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the implementation of recommended nephroprotective measures in critically ill patients suffering from moderate to severe acute kidney injury (AKI). AKI is a significant global health issue, particularly in hospitalized patients, and can lead to chronic kidney disease if not managed properly. The study focuses on the adherence to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, which propose a bundle of supportive measures aimed at preventing the progression of kidney injury. By assessing current practices, the study aims to identify gaps in care and improve outcomes for patients with AKI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Critically ill patients with moderate or severe AKI (KDIGO stage 2 / 3)
2. Requirement of vasopressors or mechanical ventilation
3. Age ≥ 18 years
4. Informed consent

Exclusion Criteria:

1. Chronic kidney disease (CKD) with a glomerular filtration rate \< 20ml/min
2. Chronic dialysis dependency
3. History of renal transplantation
4. Permanent ligation of the renal arteries
5. AKI immediately following nephrectomy
6. Patients requiring permanent administration of nephrotoxic drugs (e.g. immunosuppressive therapy afer liver transplantation)
7. Persons with any kind of dependency on the investigator or employed by the sponsor or investigator.

Where it's running

• Universitätsklinik Innsbruck
  Innsbruck, Austria Recruiting
• University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
  Münster, Germany Recruiting
• Radboud University medical cener
  Nijmegen, Netherlands Recruiting

Study contacts

• Principal investigator: Alexander Zarbock, MD — University Münster
• Study coordinator: Melanie Meersch-Dini, MD
• Email: meersch@uni-muenster.de
• Phone: +492518347255

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.