VExUS ultrasound-guided fluid management during thoracic surgery with one-lung ventilation
Official title: Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery
Run by University of Crete · NCT07258875 · Data updated 2026-11-12
This trial will test whether using a VExUS ultrasound-guided goal-directed fluid plan during thoracic surgery with one-lung ventilation reduces postoperative lung complications and acute kidney injury.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 230 (estimated) |
| Sponsor | University of Crete Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Heraklion, Crete) |
| Status | Recruiting |
| Started | November 27, 2024 |
| Main results expected | November 1, 2028 |
| Study ends | November 1, 2029 |
| Registry record updated | December 2, 2025 |
| Trial ID | NCT07258875 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 undergoing video-assisted thoracic lobectomy with planned one-lung ventilation who do not meet exclusion criteria are the intended participants.
✕Probably not a fit
Patients with severe heart failure (EF <35%), significant tricuspid regurgitation or pulmonary hypertension, advanced liver disease or portal hypertension, stage 4+ CKD or dialysis, pneumonectomy, or large physiologic IVC (young athletes) are excluded and unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Perioperative fluid balance in thoracic surgery is challenging because too much fluid can cause lung edema while too little can cause hypoperfusion and kidney injury. In this interventional study, patients undergoing video-assisted thoracic surgery/lobectomy with one-lung ventilation will receive either a VExUS ultrasound–guided goal-directed fluid protocol or standard perioperative fluid care. The trial will track postoperative pulmonary complications and the occurrence of acute kidney injury, along with intraoperative fluid volumes and hemodynamic support. The study is conducted at the University General Hospital of Heraklion and excludes patients with severe cardiac, hepatic, or advanced renal disease and those undergoing pneumonectomy.
Why it matters
Potential benefit: If successful, the VExUS-guided approach could lower rates of postoperative pulmonary complications and acute kidney injury by better matching fluid administration to each patient's venous status.
How similar studies have gone: Ultrasound-guided and venous congestion (VExUS) approaches have shown promise in detecting venous overload and guiding fluids in other settings, but their use specifically for thoracic surgery and one-lung ventilation is novel with limited direct evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults \>18 years undergoing video assisted thoracic surgery/ lobectomy requiring one-lung ventilation. Exclusion Criteria: * Refusal to participate. * Pneumonectomy. * Young athletes (risk of physiologically large IVC \>2 cm). * Moderate-severe tricuspid regurgitation, moderate to severe pulmonary hypertension * Heart failure with reduced ejection fraction, EF\<35% * Portal hypertension, portal vein thrombosis, or liver cirrhosis. * Stage 4 or end-stage chronic kidney disease (eGFR \<30 mL/min/1.73 m² or dialysis). * Transfusion with more than 2 packed red blood cells unit perioperatively (intraoperatively, in the PACU, in the ward)
Where it's running
-
University General Hospital of Heraklion
Heraklion, Crete, Greece Recruiting
Study contacts
- Study coordinator: Alexandros Bogas Manouselis, Resident of Anaesthesiology
- Email: bogas.alexandros@gmail.com
- Phone: +306947545446
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.