Restarting RAS inhibitors after AKI: a quick test in hospitalized adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a small, randomized pilot trial comparing an early restart of RAS inhibitors to usual care in adults with AKI who were previously on RASi therapy. Participants are rehospitalized patients whose RASi were paused during AKI; the study measures feasibility, tolerability, and a 90-day follow-up with labs and questions. The goal is to gather data to inform a larger definitive trial on whether early restart improves subsequent RASi use and health outcomes. The study uses a predefined protocol for restarting RASi and includes safety monitoring and follow-up assessments. Enrollment targets 60 participants (30 per arm) at the UCSF site with NIDDK support as a collaborator.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Pre-admission RASi use for Class I indication (e.g., heart failure, kidney disease)
* RASi stopped in the setting of AKI (defined by ≥1.5x baseline SCr)
* AKI in recovery (defined by a decrease in SCr by ≥0.3mg/dL from peak)

Exclusion Criteria:

* RASi allergy or contraindication (i.e., angioedema, bilateral renal artery stenosis)
* Ongoing dialysis requirement
* Pregnant or breastfeeding
* Prisoner
* Palliative or hospice care involvement
* Unable to consent
* No enteral route of medication administration
* Clinician judgment

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Yuenting D Kwong, MD MAS — University of California, San Francisco
• Study coordinator: Yuenting D Kwong, MD MAS
• Email: diana.kwong@ucsf.edu
• Phone: 415-514-7371

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.