Investigating the role of angiopoietins in cardiac surgery outcomes
Angiopoietin Dysregulation to Predict Adverse Outcomes in Cardiac Surgery: the Prospective
This study is trying to see if measuring certain proteins in the blood can help predict complications for adults having heart surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Trial ID | NCT05817929 on ClinicalTrials.gov |
What this trial studies
This study examines the relationship between angiopoietin levels and adverse outcomes in patients undergoing cardiac surgery with cardiopulmonary bypass. It focuses on how dysregulation of angiopoietin 1 and 2 may indicate endothelial injury and systemic organ failure. By analyzing blood samples from adult patients scheduled for cardiac surgery, the researchers aim to identify potential biomarkers for predicting complications such as acute kidney injury. The findings could enhance understanding of the inflammatory processes involved in cardiac surgery.
Who should consider this trial
Good fit: Ideal candidates are adult patients scheduled for cardiac surgery involving cardiopulmonary bypass.
Not a fit: Patients under 18, those requiring urgent surgery, or those with specific cardiac conditions like endocarditis or aortic dissection may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients undergoing cardiac surgery.
How similar studies have performed: While the specific approach of assessing angiopoietin dysregulation in this context may be novel, similar studies have explored biomarkers in cardiac surgery with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patient scheduled for cardiac surgery under cardiopulmonary bypass Exclusion Criteria: * patient less than 18 years old, * redo surgery, * urgent surgery, * endocarditis, * aortic root repair surgery * aortic dissection * heart beating surgery, * heart transplantation
Where this trial is running
Amiens
- CHU Amiens Picardie — Amiens, France (Recruiting)
Study contacts
- Study coordinator: Osama ABOU ARAB, MD
- Email: abouarab.osama@chu-amiens.fr
- Phone: 03 22 08 78 36
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.