Investigating the role of angiopoietins in cardiac surgery outcomes
Official title: Angiopoietin Dysregulation to Predict Adverse Outcomes in Cardiac Surgery: the Prospective
Run by Centre Hospitalier Universitaire, Amiens · NCT05817929 · Data updated 2026-11-12
This study is trying to see if measuring certain proteins in the blood can help predict complications for adults having heart surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | March 23, 2023 |
| Main results expected | April 2026 |
| Study ends | April 2027 |
| Registry record updated | May 25, 2025 |
| Trial ID | NCT05817929 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult patients scheduled for cardiac surgery involving cardiopulmonary bypass.
✕Probably not a fit
Patients under 18, those requiring urgent surgery, or those with specific cardiac conditions like endocarditis or aortic dissection may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the relationship between angiopoietin levels and adverse outcomes in patients undergoing cardiac surgery with cardiopulmonary bypass. It focuses on how dysregulation of angiopoietin 1 and 2 may indicate endothelial injury and systemic organ failure. By analyzing blood samples from adult patients scheduled for cardiac surgery, the researchers aim to identify potential biomarkers for predicting complications such as acute kidney injury. The findings could enhance understanding of the inflammatory processes involved in cardiac surgery.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients undergoing cardiac surgery.
How similar studies have gone: While the specific approach of assessing angiopoietin dysregulation in this context may be novel, similar studies have explored biomarkers in cardiac surgery with varying degrees of success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patient scheduled for cardiac surgery under cardiopulmonary bypass Exclusion Criteria: * patient less than 18 years old, * redo surgery, * urgent surgery, * endocarditis, * aortic root repair surgery * aortic dissection * heart beating surgery, * heart transplantation
Where it's running
-
CHU Amiens Picardie
Amiens, France Recruiting
Study contacts
- Study coordinator: Osama ABOU ARAB, MD
- Email: abouarab.osama@chu-amiens.fr
- Phone: 03 22 08 78 36
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.