Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Investigating the role of angiopoietins in cardiac surgery outcomes

Official title: Angiopoietin Dysregulation to Predict Adverse Outcomes in Cardiac Surgery: the Prospective

Run by Centre Hospitalier Universitaire, Amiens · NCT05817929 · Data updated 2026-11-12

This study is trying to see if measuring certain proteins in the blood can help predict complications for adults having heart surgery.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorCentre Hospitalier Universitaire, Amiens
Academic / other
Locations1 site (Amiens)
StatusRecruiting
StartedMarch 23, 2023
Main results expectedApril 2026
Study endsApril 2027
Registry record updatedMay 25, 2025
Trial IDNCT05817929 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adult patients scheduled for cardiac surgery involving cardiopulmonary bypass.

Probably not a fit

Patients under 18, those requiring urgent surgery, or those with specific cardiac conditions like endocarditis or aortic dissection may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the relationship between angiopoietin levels and adverse outcomes in patients undergoing cardiac surgery with cardiopulmonary bypass. It focuses on how dysregulation of angiopoietin 1 and 2 may indicate endothelial injury and systemic organ failure. By analyzing blood samples from adult patients scheduled for cardiac surgery, the researchers aim to identify potential biomarkers for predicting complications such as acute kidney injury. The findings could enhance understanding of the inflammatory processes involved in cardiac surgery.

Why it matters

Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients undergoing cardiac surgery.

How similar studies have gone: While the specific approach of assessing angiopoietin dysregulation in this context may be novel, similar studies have explored biomarkers in cardiac surgery with varying degrees of success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* adult patient scheduled for cardiac surgery under cardiopulmonary bypass

Exclusion Criteria:

* patient less than 18 years old,
* redo surgery,
* urgent surgery,
* endocarditis,
* aortic root repair surgery
* aortic dissection
* heart beating surgery,
* heart transplantation

Where it's running

  • CHU Amiens Picardie
    Amiens, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.