Understanding brain health in ICU patients with kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the neurocognitive outcomes of critically ill adults who have experienced acute kidney injury and are undergoing kidney replacement therapy. It focuses on measuring regional cerebral oxygen saturation as a potential early indicator of long-term cognitive impairment. By correlating these measurements with cognitive and functional outcomes, the study aims to shed light on the relationship between kidney therapy and brain health in ICU patients. The research is conducted at the Kingston Health Sciences Centre.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age greater than or equal to 18 years
* admitted to the Kingston Health Sciences Intensive Care Unit
* diagnosis of severe AKI requiring Kidney Replacement Therapy (KRT) (defined by the presence of either a twofold increase in serum creatinine from baseline, serum creatinine level greater than or equal to 354 micromol/L with an increase of 27 micromol/L from baseline, or urine output \<6 mL/kg in the preceding 12 hours)
* within 12 hours of initiation of KRT via intermittent hemodialysis (iHD) or continuous kidney replacement therapy (CKRT).

Exclusion Criteria:

* acquired or congenital neurological disorders
* any contraindication to testing with cerebral oximetry, Kinarm, or MRI (e.g., claustrophobia, limb amputation, paresis, neuromuscular disorders, etc.)
* KRT via PD
* failure to consent
* life expectancy less than 24 hours
* clinical suspicion of renal obstruction
* rapidly progressive glomerulonephritis or interstitial nephritis
* prehospitalization eGFR \<30 mL/min/1.73m2.

Where it's running

• Kingston Health Sciences Centre
  Kingston, Ontario, Canada Recruiting

Study contacts

• Study coordinator: J. Gordon Boyd, MD, PhD
• Email: gordon.boyd@kingstonhsc.ca
• Phone: 613-549-6666

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.