Condition

Acute Decompensated Heart Failure clinical trials and research

• 14Clinical trials
• 2NIH research projects
• 14Countries

Newest Acute Decompensated Heart Failure clinical trials

All recruiting trials (14)

• Evaluating a noninvasive tissue sensor to detect cardiogenic shock earlier in heart patients

  This pilot, noninvasive study tests whether the NIRSense wearable can help detect deterioration in adults with cardiogenic shock risk due to heart attack or heart failure.

  Recruiting NIRSense Inc. · Weston, Florida · NCT07825363

• BEAT-SHOCK: Baseline Registry for Acute Cardiogenic Shock at Basel

  This registry collects and shares data on adults with cardiogenic shock admitted to University Hospital Basel to help understand how these patients are treated and how they fare.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT07643610

• Daily lung ultrasound to see if it shortens hospital stays for adults with acute decompensated heart failure

  This study tests whether daily lung ultrasound can shorten hospital stays and reduce readmissions for adults with acute decompensated heart failure.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07572955

• Adding extra diuretics to standard care for acute decompensated heart failure

  This trial will test whether adding empagliflozin, acetazolamide, or metolazone to loop diuretics helps adults hospitalized with acute decompensated heart failure remove fluid and feel better.

  Recruiting Phase 2 Tanta University · Tanta · NCT07372040

• Acetazolamide versus metolazone added to usual diuretics for acute decompensated heart failure

  This trial will test whether adding acetazolamide or metolazone to standard diuretics works better and is safer for adults hospitalized with acute decompensated heart failure.

  Recruiting University of Health Sciences Lahore · Chak Eighty-seven -Twelve Left, Punjab Province · NCT07199088

• Fluid removal with the Reprieve System for acute decompensated heart failure

  This trial will test whether the Reprieve System removes excess fluid more effectively than standard IV diuretics in adults hospitalized with acute decompensated heart failure who are at risk for diuretic resistance.

  Recruiting at 49 sites Reprieve Cardiovascular, Inc · Irvine, California and 49 other locations · NCT06898515

• Using ultrasound to guide treatment for heart failure patients

  This study is testing if using ultrasound to guide treatment can help hospitalized heart failure patients feel better by managing fluid buildup in their bodies.

  Recruiting Oslo University Hospital · Oslo · NCT06714409

• Using the Reprieve System to relieve heart failure symptoms

  This study is testing if the Reprieve System can help relieve symptoms for people in the hospital with acute heart failure.

  Recruiting Reprieve Cardiovascular, Inc · Tbilisi · NCT06272734

• Early comprehensive rehabilitation for patients with acute decompensated heart failure

  This study is testing if a 6-week rehabilitation program that includes exercise can help improve the quality of life for people with acute heart failure compared to regular care.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT06161987

• Registry of patients with acute cardiovascular disease in a cardiac intensive care unit

  This study is looking at patients with serious heart conditions in the Cardiac Intensive Care Unit to see how they do during and after their hospital stay.

  Recruiting University Hospital, Ioannina · Ioannina, Epirus · NCT06081205

• Evaluating the Nephronyx System for treating acute heart failure

  This study is testing a new system called Nephronyx to see if it can help hospitalized patients with acute heart failure who are struggling with fluid buildup and not getting better with regular treatments.

  Recruiting at 4 sites Nephronyx LTD · Haifa and 3 other locations · NCT05759806

• Education tailored to your health literacy to help follow heart-care instructions after a heart attack or heart failure

  This trial tests whether an educational toolkit adapted for people with limited health literacy helps patients hospitalized for a heart attack or worsening heart failure follow medical recommendations and avoid readmission.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron and 3 other locations · NCT03951467

• Non-invasive stimulation of the tragus to reduce inflammation in heart failure patients

  This study is testing if a new way of stimulating a small nerve in the ear can help reduce inflammation and improve heart function in patients with severe heart failure.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT02898181

• Investigating blood proteins related to heart failure

  This study is trying to see if two specific proteins in the blood can help identify when people with heart failure are having a worsening episode.

  Recruiting UConn Health · Farmington, Connecticut · NCT00762008

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using deep learning to improve lung ultrasound assessments for heart failure in emergency patients

  This study is looking at how to make it easier and faster for doctors in the Emergency Department to check for heart failure in patients by using smart technology to analyze lung ultrasound images, helping you get the care you need more quickly.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10888388

• Investigating kidney injury in patients with acute heart failure

  This study is looking at how kidney problems happen in people with heart failure and aims to find new ways to spot these issues quickly, so doctors can make better treatment choices and help patients feel better.

  NIH research University of Washington · Seattle, United States · NIH-10835916

Related topics

Quick answers

How many Acute Decompensated Heart Failure clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (5 trials), Egypt (1 trial), Israel (1 trial), Norway (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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