Can Timps2 and IGFBP7 Urine Test Help Flag High-Risk AKI in Septic Shock Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In septic shock, acute kidney injury is common and can worsen to severe stages. This observational study reanalyzes data from previous septic shock cohorts to see if the Nephrocheck urine test can predict which patients will progress to KDIGO stage 3 AKI. The test measures two markers of kidney tubular injury in urine to help flag at-risk patients. Researchers will assess whether TIMP2 and IGFBP7 levels correlate with progression and potential need for renal replacement therapy. Results could guide earlier intervention and resource planning in ICUs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 or over
* Septic shock (according to Bone's criteria) within 4 hours of introduction of catecholamines
* AKI, characterized by a KDIGO score ≥ 1
* Social security coverage

Exclusion Criteria:

* AKI requiring emergency RRT (in the critical care physician's opinion).
* Anuria
* Stage 4-5 chronic kidney failure with a GFR below 30 ml/min.
* Rapidly progressing renal disorders (glomerulonephritis, HUS, blockage, etc.)
* Obstructive AKI
* Probable glomerular damage (nephritic syndrome, nephrotic syndrome, chronic glomerulonephritis)
* Pregnancy or breastfeeding
* Legal guardianship or lack of social security coverage.
* Cardiocirculatory arrest
* Life expectancy \<48 hours.
* Child C cirrhosis
* Prior occurrence of AKI during the current hospital stay
* Transplantation
* Subject participating in another study with an exclusion period ongoing at the time of the pre-inclusion

Where it's running

• CHU Amiens-Picardie
  Amiens, France Recruiting

Study contacts

• Principal investigator: Julien Maizel — CHU Amiens-Picardie
• Study coordinator: Julien MAIZEL, PU-PH
• Email: maizel.julien@chu-amiens.fr
• Phone: +33 322087807

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.