Kidney oxygen monitoring with near-infrared light during lung transplant surgery
Official title: Association Between Renal Regional Oxygen Saturation Measured by Near-InfraRed Spectroscopy and Postoperative Renal Failure After Lung Transplantation Surgery: A Pilot Study
Run by Assistance Publique Hopitaux De Marseille · NCT05836922 · Data updated 2026-11-12
This project tests whether watching kidney oxygen levels with near-infrared light during lung transplant surgery can help predict which adults will develop postoperative acute kidney failure.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Status | Recruiting |
| Started | March 23, 2024 |
| Main results expected | September 28, 2026 |
| Study ends | September 28, 2026 |
| Registry record updated | February 23, 2026 |
| Trial ID | NCT05836922 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) undergoing single or bilateral lung transplantation at the Marseille center who are covered by the French social security system and do not have excluded conditions like single kidney, polycystic kidney, hyperbilirubinemia > 17mmol/l, preoperative ECMO, or preoperative mechanical ventilation.
✕Probably not a fit
Patients with renal anatomical abnormalities (single kidney, polycystic kidney), marked hyperbilirubinemia, those on preoperative ECMO or mechanical ventilation, or patients treated outside the Marseille surgical center are not eligible and are unlikely to benefit from this monitoring approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a pilot observational study that records renal regional oxygen saturation using near-infrared spectroscopy (NIRS) during single or bilateral lung transplantation. Researchers will correlate intraoperative renal NIRS readings with postoperative acute kidney injury and the need for renal replacement therapy. Eligible participants are adults (≥18) undergoing lung transplant at the Marseille center, while patients with renal anatomical abnormalities, high bilirubin, preoperative ECMO, or preoperative mechanical ventilation are excluded. There is no interventional change to standard care; the goal is to see if bedside NIRS signals identify intraoperative renal hypoxia linked to later kidney failure.
Why it matters
Potential benefit: If successful, this could provide a bedside way to detect renal hypoxia during surgery and prompt actions that reduce postoperative acute kidney injury and the need for dialysis.
How similar studies have gone: Near-infrared spectroscopy has shown promise for detecting renal desaturation in other surgical settings, but its use specifically during lung transplantation is novel and not yet validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient undergoing a lung transplant (mono or bi-transplantation) * Age \>= 18 years * Affiliated to the French social security system Exclusion Criteria: * Renal anatomical abnormality likely to induce a misleading NIRS signal: single kidney, polycystic kidney disease. * Expression of opposition to participation in the research protocol. * Hyperbilurbinemia \> 17mmol/l * Preoperative Extra Corporeal Membran Oxygenation (ECMO). * Preoperative mechanical ventilation
Where it's running
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Service d'anesthésie et réanimation adulte
Marseille, France Recruiting
Study contacts
- Study coordinator: Pierre Mora
- Email: pierre.mora@ap-hm.fr
- Phone: 0491965537
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.