Investigating kidney injury related to sepsis
Investigations Into the Mechanisms for Bioenergetic Failure in Sepsis-associated Acute Kidney Injury
University Hospital of North Norway · NCT05694624
This study looks at how sepsis affects kidney function and energy use in patients with kidney injury compared to healthy people having surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | University Hospital of North Norway (other) |
| Locations | 1 site (Tromsø, Troms) |
| Trial ID | NCT05694624 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the metabolic and hemodynamic disturbances in patients experiencing sepsis-associated acute kidney injury (AKI) compared to healthy controls undergoing laparoscopic abdominal surgery. The researchers will investigate renal metabolism and bioenergetics, focusing on the activity of specific enzymes and metabolites related to energy supply in the kidneys. By analyzing variables such as renal oxygenation, glomerular filtration rate, and mitochondrial respiration, the study seeks to enhance understanding of the pathobiology of sepsis-associated AKI and its potential causes.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed or suspected of having sepsis with normal premorbid serum creatinine levels.
Not a fit: Patients with pre-existing kidney conditions or those not diagnosed with sepsis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of acute kidney injury in septic patients, potentially reducing mortality rates.
How similar studies have performed: While there have been studies on acute kidney injury, this specific investigation into the metabolic pathways related to sepsis-associated AKI is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria sepsis group: * Sepsis diagnosed or suspected * Normal premorbid serum creatinine measured or anticipated (if data are not available) * Normovolemia as indicated by a pulse pressure variation less than 12% Comparator group * Previously healthy individuals scheduled for laparoscopic colon cancer resection * Normal creatinine levels within 3 months before admittance to hospital. * Patients admitted to the intensive care unit with sepsis diagnosed or suspected * Previously healthy patients listed for elective colon cancer surgery Exclusion Criteria: \-
Where this trial is running
Tromsø, Troms
- University Hospital of North Norway — Tromsø, Troms, Norway (RECRUITING)
Study contacts
- Principal investigator: Lars MG Ytrebø — University Hospital of North Norway
- Study coordinator: Lars M Ytrebo, MD PhD
- Email: lars.marius.ytrebo@unn.no
- Phone: +4790788058
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Kidney Injury