Investigating kidney injury related to sepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the metabolic and hemodynamic disturbances in patients experiencing sepsis-associated acute kidney injury (AKI) compared to healthy controls undergoing laparoscopic abdominal surgery. The researchers will investigate renal metabolism and bioenergetics, focusing on the activity of specific enzymes and metabolites related to energy supply in the kidneys. By analyzing variables such as renal oxygenation, glomerular filtration rate, and mitochondrial respiration, the study seeks to enhance understanding of the pathobiology of sepsis-associated AKI and its potential causes.

Why it matters

Who can join: the full rules

Inclusion Criteria sepsis group:

* Sepsis diagnosed or suspected
* Normal premorbid serum creatinine measured or anticipated (if data are not available)
* Normovolemia as indicated by a pulse pressure variation less than 12%

Comparator group

* Previously healthy individuals scheduled for laparoscopic colon cancer resection
* Normal creatinine levels within 3 months before admittance to hospital.

  * Patients admitted to the intensive care unit with sepsis diagnosed or suspected
  * Previously healthy patients listed for elective colon cancer surgery

Exclusion Criteria:

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Where it's running

• University Hospital of North Norway
  Tromsø, Troms, Norway Recruiting

Study contacts

• Principal investigator: Lars MG Ytrebø — University Hospital of North Norway
• Study coordinator: Lars M Ytrebo, MD PhD
• Email: lars.marius.ytrebo@unn.no
• Phone: +4790788058

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.