Perioperative GFR Monitoring to Predict CSA-AKI and CA-AKI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects continuous perioperative GFR data using a fluorescence-based tracer to see if GFR trajectories can forecast CSA-AKI and CA-AKI before standard criteria are met. Participants are adults undergoing elective cardiovascular surgery, CTA, or PCI who receive the fluorescent tracer. Researchers compare GFR trajectories with subsequent AKI development and severity to identify early patterns. Data will include perioperative and peri-contrast hemodynamics and other clinical characteristics to contextualize the findings. The goal is to determine whether real-time kidney function monitoring can enable earlier recognition of AKI risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years old;
2. Specific inclusion criteria for the cohort:

   * GFR trajectory characterization after cardiovascular surgery or Iodine contrast agent exposure: Patients scheduled for elective cardiovascular surgery or interventional cardiovascular surgery or CTA; ② GFR trajectory characterization of AKI: Patients with confirmed CSA-AKI or contrast-associated acute kidney injury (CA-AKI).

Exclusion Criteria:

1. Received renal replacement therapy before surgery or before contrast imaging, including kidney transplantation and regular dialysis;
2. Serum creatinine \> 353 μmol/L before surgery or before contrast imaging;
3. Patients with AKI who did not recover before surgery or before contrast imaging;
4. Patients with malignant tumors.

Where it's running

• Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Cardiovascular Diseases
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Jianfang Cai
• Email: caijfbj@126.com
• Phone: +86 15801601007

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Remote Ischemic Preconditioning at Different Times After Heart Valve Surgery

  This study tests whether applying brief, controlled blood-flow restrictions to a limb at different times after heart valve surgery can help protect organs and reduce complications like kidney injury.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07888634

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Biomarkers to predict CSA-AKI risk before heart surgery

  This study tests new biomarkers to see if they can predict CSA-AKI risk in adults undergoing cardiovascular surgery.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07811570

• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

  This trial tests whether using the oXiris hemofilter during continuous kidney replacement helps lower endotoxin levels in adults with septic shock who need CRRT.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07807410

• Restarting RAS inhibitors after AKI: a quick test in hospitalized adults

  This pilot study tests whether restarting renin-angiotensin system inhibitors early after acute kidney injury is feasible and safe in hospitalized adults already using these medicines.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07734636

• FST Decision Support to Help Timely Therapy for Kids with AKI Risk

  This study tests whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe AKI.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07718464

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.