Comparing two methods of anticoagulation in kidney treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of two different anticoagulation methods during Sustained Low-Efficiency Dialysis (SLED) for patients requiring renal replacement therapy. It compares the use of a 4% citrate infusion against a calcium-free dialysate to determine which method better prevents complications associated with blood contact in the extracorporeal circuit. The goal is to reduce risks and costs associated with anticoagulation in patients undergoing intermittent renal replacement therapy. The study aims to provide insights into safer and more efficient treatment options for acute kidney injury.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All patient requiring Renal replacement Therapy

Exclusion Criteria:

* Age \< 18 years
* Pregnancy
* Hypercalcemia ≥ 3 mmol/L.
* Major under guardianship
* Major deprived of freedom
* Impossible to obtain free and informed consent
* Presence of hemostasis or coagulation disorders:
* Thrombocytopenia \< 30 G/L.
* Curative anticoagulation.
* Severe liver disease with Prothrombin rate \<30%.
* Coagulation factor deficit.
* Not registered to a social security system.

Where it's running

• Groupe Hospitalier Sud Ile-de-France
  Melun, France Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.