Comparing low and standard dose-intensity continuous renal replacement therapy in critically ill patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The WISDOM trial aims to evaluate whether a lower dose-intensity of continuous renal replacement therapy (CRRT) is as effective as the standard dose-intensity for critically ill patients suffering from acute kidney injury (AKI). This interventional study will compare the outcomes of patients receiving lower dose-intensity CRRT against those receiving the standard guideline-directed dose. The primary goal is to determine if the lower dose is non-inferior in terms of CRRT duration and kidney recovery. Additionally, the study will assess if the lower dose can lead to shorter CRRT duration and improved recovery outcomes. This trial is significant as it addresses a gap in current clinical guidelines regarding the minimum effective dose of CRRT.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age ≥ 18 years
* weight ≥ 55 kg
* plan to initiate CRRT or within 24 hours of having started CRRT for AKI
* expected to survive and receive CRRT for a duration of ≥ 48 hours
* able to provide informed consent or have an authorized representative provide consent after being informed on the details and risks of the trial unless a deferred consent process is approved by local Research Ethics Board (REB).

Exclusion Criteria:

* indication for sustained higher dose-intensity CRRT as designated by the attending clinicians
* end-stage kidney disease receiving maintenance dialysis
* receipt of any RRT for AKI during the current hospitalization
* inability to comply with the requirements of the study protocol.

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting
• Foothills Medical Centre
  Calgary, Alberta, Canada Recruiting
• University of Alberta Hospital
  Edmonton, Alberta, Canada Recruiting
• Grey Nuns Hospital
  Edmonton, Alberta, Canada Recruiting
• Sturgeon Community Hospital
  St. Albert, Alberta, Canada Recruiting
• Hamilton General Hospital
  Hamilton, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Sean M Bagshaw, MD — University of Alberta
• Study coordinator: Sean M Bagshaw, MD
• Email: bagshaw@ualberta.ca
• Phone: 780-248-1256

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.