Improving understanding of acute kidney injury in older veterans
Official title: Advancing the Phenotyping of Acute Kidney Injury for the Million Veterans Program
Funded at Veterans Health Administration · NIH-11291839 · Data updated 2026-11-12
This study is looking at how genetics might affect the risk of serious kidney problems in older veterans, with the hope of finding better ways to treat and help those who develop acute kidney injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2019 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01HX002489-07 |
| Project ID | NIH-11291839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans aged 65 and older who are at risk for acute kidney injury.
✕Less likely to help
Patients under the age of 65 or those without risk factors for acute kidney injury may not benefit from this research.
What this research studies
This research focuses on acute kidney injury (AKI), a serious condition that can lead to long-term kidney damage and other health issues, particularly in older veterans. The study aims to enhance the understanding of the genetic factors that contribute to the risk of developing intrinsic AKI, which is the most severe form of the condition. By employing advanced techniques like genome-wide association studies and improved phenotyping methods, the research seeks to identify distinct subtypes of AKI to better tailor treatments. The ultimate goal is to translate these findings into effective clinical practices that can improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for acute kidney injury in older veterans, potentially reducing mortality and improving quality of life.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to acute kidney injury, but this study aims to take a novel approach by focusing on a larger, more diverse veteran population.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Siew, Edward D — Veterans Health Administration
- Study coordinator: Siew, Edward D
Related research
Other NIH-funded projects on the same topics.
-
SEAK Alliance: Improving Care for AKI Patients in the Southeast
A national, patient-centered effort to improve post-hospital care for people who had acute kidney injury in the Southeast.
-
AKI-related delirium after heart surgery
This grant funds research to understand why some people develop delirium after heart surgery when they also have acute kidney injury.
-
Better ways to identify types of sudden kidney injury in U.S. Veterans
Researchers are looking for genetic and health patterns that define different types of sudden severe kidney injury in Veterans to help guide future care.
-
Neuroimmune control of kidney injury using noninvasive ultrasound
A new approach uses targeted ultrasound to gently stimulate nerves and immune signals to help the kidney recover after injury.
-
Structure-based approach to prevent kidney injury from polymyxin use
Aims to block how polymyxin damages the kidney so it can be used more safely to treat hard-to-kill infections.
-
Using smart computer predictions to prevent kidney injury after heart surgery
A machine-learning approach uses routinely collected hospital data to predict who might develop acute kidney injury after heart surgery, so clinicians can act early.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.