Comparing sodium levels in dialysis for ICU patients with kidney injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of different sodium concentrations in dialysate on hemodynamic tolerance and fluid overload in ICU patients suffering from acute kidney injury (AKI) requiring renal replacement therapy. The study compares two groups of patients receiving sustained low efficiency daily dialysis-filtration (SLEDD-f) with dialysate sodium concentrations of 140 mmol/l and 145 mmol/l. The goal is to determine if a lower sodium concentration can maintain hemodynamic stability while reducing the risk of fluid overload, which is associated with higher mortality in critically ill patients. Participants will be monitored over a 7-day period to assess their response to the different sodium levels.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Age \> 18 years old
* Acute kidney injury requiring renal replacement therapy
* Dialysis type: on line sustained low efficiency dialy dialysis -filtration
* SOFA score \> 5
* Sodium serum level between 135 and 145mmol/l

Exclusion criteria:

* Chronic kidney disease stade IV ou V
* Obstrutive acute kidney injury
* Renal tansplantation in the year before ICU admission
* Moribund with risk of death in the 48 hours
* Vulnerable persons or protected persons
* Pregnant or breastfeeding mother

Where it's running

• Uhmontpellier
  Montpellier, Montpellier, France Recruiting

Study contacts

• Principal investigator: vincent BRUNOT, MD — University Hospital, Montpellier
• Study coordinator: vincent BRUNOT, MD
• Email: v-brunot@chu-montpellier.fr
• Phone: 467332495

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.