Using remote ischemic preconditioning to protect kidneys and heart in heart failure patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The RICH Trial is a multicenter, randomized clinical trial designed to evaluate the effects of remote ischemic preconditioning on patients with congestive heart failure undergoing cardiac procedures. This study aims to assess its impact on contrast-associated acute kidney injury, functional capacity, and major adverse kidney events. Participants will be randomly assigned to receive either the remote ischemic preconditioning treatment or a sham procedure, with outcomes measured at one and three months post-procedure. The trial focuses on patients with reduced left ventricular ejection fraction and aims to provide insights into improving kidney and heart health during cardiac interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years
* Diagnosis of heart failure with reduced LVEF \<50%
* Pre-procedure intravenous normal saline fluid restriction status
* Society for Cardiovascular Angiography and Interventions (SCAI) AKI risk score (\>1%)
* Referral for coronary angiogram and/or PCI
* Suspected stable coronary artery disease or acute coronary syndrome

Exclusion Criteria:

* Inability to give informed consent
* Unstable BP (SBP \> 200 or \<80 mmHg) at the time of enrolment
* Upper limb peripheral arterial disease
* Unavailability of at least one arm for RIPC/Sham-RIPC application
* Kidney transplant
* Renal disease requiring dialysis
* Prior exposure to contrast media within 72hrs preceding coronary angiography
* Pregnancy
* Prisoner

Where it's running

• VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
  Pittsburgh, Pennsylvania, United States Recruiting
• VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
  Dallas, Texas, United States Recruiting
• Hunter Holmes McGuire VA Medical Center, Richmond, VA
  Richmond, Virginia, United States Recruiting

Study contacts

• Principal investigator: Oladipupo Olafiranye, MD MS — VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
• Study coordinator: Oladipupo Olafiranye, MD MS
• Email: Oladipupo.Olafiranye@va.gov
• Phone: (214) 857-2923

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.