Citrate anticoagulation protocol to stabilize electrolytes during continuous renal replacement in ICU adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Electrolyte disturbances are common during CRRT with regional citrate anticoagulation and can increase the need for electrolyte supplementation. This non-randomized, sequential interventional comparison tests CVVHDF with post-filter replacement against historical controls treated with standard CVVHD. Adult patients (≥18) admitted to the multidisciplinary ICU at Hospital de la Santa Creu i Sant Pau who require CRRT and can receive citrate anticoagulation are included. The primary outcome is reduction in electrolyte supplementation during the period of CRRT, with data collection ending when CRRT is discontinued.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Age ≥18 years
* Admission to the intensive care unit (ICU)
* Diagnosis of acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT)
* Use of regional citrate anticoagulation during CRRT Exclusion Criteria
* Known allergy or intolerance to citrate
* Contraindications to citrate anticoagulation (e.g., severe liver failure or severe metabolic disorders affecting citrate metabolism)
* Pregnancy or breastfeeding

Where it's running

• Hospital de la Santa Creu i Sant Pau
  Barcelona, Barcelona, Spain Recruiting

Study contacts

• Study coordinator: Ana Jiménez Valenzuela, Nurse
• Email: ajimenezva@santpau.cat
• Phone: +34935537796

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.