Flozins to prevent contrast-related kidney injury after coronary angiography or PCI
Official title: FLOzins for pREveNtion of Contrast-inducEd Acute Kidney Injury (FLORENCE) Study
Run by Collegium Medicum w Bydgoszczy · NCT07231939 · Data updated 2026-11-12
This project tests whether taking a flozin (empagliflozin or dapagliflozin), short-term or long-term, lowers the chance of contrast-induced acute kidney injury in patients having coronary angiography or PCI.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 4000 (estimated) |
| Sponsor | Collegium Medicum w Bydgoszczy Academic / other |
| Locations | 1 site (Bydgoszcz) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | December 31, 2025 |
| Study ends | March 31, 2026 |
| Registry record updated | November 17, 2025 |
| Trial ID | NCT07231939 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for inclusion are patients who underwent coronary angiography or PCI at Collegium Medicum w Bydgoszczy during the study period with documented contrast volume between 50 and 500 mL and available pre- and post-procedure serum creatinine measurements.
✕Probably not a fit
Patients with contrast volumes under 50 mL or over 500 mL, or with missing creatinine data, are excluded and therefore would not benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective, single-centre cohort/case-control analysis of all consecutive patients who underwent coronary angiography or PCI at Collegium Medicum w Bydgoszczy between 01.01.2020 and 30.09.2025. The final analysis includes only procedures with iodine contrast volume between 50 and 500 mL and patients with both pre- and post-procedure serum creatinine measurements. The study compares occurrence of contrast-induced AKI among patients with short-term versus long-term SGLT2 inhibitor (empagliflozin or dapagliflozin) use and will analyze baseline characteristics, contrast type and volume, and serial creatinine/eGFR changes at 24, 48, and 72 hours. Results will be combined with previously published studies in a planned meta-analysis.
Why it matters
Potential benefit: If successful, using flozins around the time of contrast exposure could reduce cases of contrast-induced AKI and related short-term kidney complications in patients undergoing coronary angiography or PCI.
How similar studies have gone: Some observational and mechanistic studies suggest SGLT2 inhibitors have renal protective effects, but direct evidence specifically preventing contrast-induced AKI is limited and this study adds to a relatively small body of data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * all consecutive patients who underwent PCI or coronary angiography during the study period for whom the variables required for the analysis are available Exclusion Criteria: * unavailability of variables required for the analysis, volume * contrast agent volume \<50 mL or \>500 mL.
Where it's running
-
Collegium Medicum w Bydgoszczy
Bydgoszcz, Poland Recruiting
Study contacts
- Principal investigator: Jacek Kubica, Prof. — Collegium Medicum w Bydgoszczy
- Study coordinator: Piotr Niezgoda, MD, PhD
- Email: piotr.niezgoda1986@gmail.com
- Phone: +48525854023
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.