Clinical trial Recruiting at 1 site Observational Ages 18 and up

Flozins to prevent contrast-related kidney injury after coronary angiography or PCI

Official title: FLOzins for pREveNtion of Contrast-inducEd Acute Kidney Injury (FLORENCE) Study

Run by Collegium Medicum w Bydgoszczy · NCT07231939 · Data updated 2026-11-12

This project tests whether taking a flozin (empagliflozin or dapagliflozin), short-term or long-term, lowers the chance of contrast-induced acute kidney injury in patients having coronary angiography or PCI.

More Coronary Artery Disease trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment4000 (estimated)
SponsorCollegium Medicum w Bydgoszczy
Academic / other
Locations1 site (Bydgoszcz)
StatusRecruiting
StartedNovember 1, 2025
Main results expectedDecember 31, 2025
Study endsMarch 31, 2026
Registry record updatedNovember 17, 2025
Trial IDNCT07231939 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for inclusion are patients who underwent coronary angiography or PCI at Collegium Medicum w Bydgoszczy during the study period with documented contrast volume between 50 and 500 mL and available pre- and post-procedure serum creatinine measurements.

Probably not a fit

Patients with contrast volumes under 50 mL or over 500 mL, or with missing creatinine data, are excluded and therefore would not benefit from this analysis.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective, single-centre cohort/case-control analysis of all consecutive patients who underwent coronary angiography or PCI at Collegium Medicum w Bydgoszczy between 01.01.2020 and 30.09.2025. The final analysis includes only procedures with iodine contrast volume between 50 and 500 mL and patients with both pre- and post-procedure serum creatinine measurements. The study compares occurrence of contrast-induced AKI among patients with short-term versus long-term SGLT2 inhibitor (empagliflozin or dapagliflozin) use and will analyze baseline characteristics, contrast type and volume, and serial creatinine/eGFR changes at 24, 48, and 72 hours. Results will be combined with previously published studies in a planned meta-analysis.

Why it matters

Potential benefit: If successful, using flozins around the time of contrast exposure could reduce cases of contrast-induced AKI and related short-term kidney complications in patients undergoing coronary angiography or PCI.

How similar studies have gone: Some observational and mechanistic studies suggest SGLT2 inhibitors have renal protective effects, but direct evidence specifically preventing contrast-induced AKI is limited and this study adds to a relatively small body of data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* all consecutive patients who underwent PCI or coronary angiography during the study period for whom the variables required for the analysis are available

Exclusion Criteria:

* unavailability of variables required for the analysis, volume
* contrast agent volume \<50 mL or \>500 mL.

Where it's running

  • Collegium Medicum w Bydgoszczy
    Bydgoszcz, Poland
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.