Predicting successful weaning from continuous renal replacement therapy in acute kidney injury patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine if changes in plasma concentration of c-cistatin can predict the optimal withdrawal time of continuous renal replacement therapy (CRRT) in patients with acute kidney injury. The study will involve patients who are naive to renal injury and are admitted to various intensive care units. By measuring c-cistatin levels from the initiation to the discontinuation of CRRT, researchers hope to identify a reliable biomarker for weaning off renal support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age ≥ 18 years;
* diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria)
* need for support with CRRT according to the indications of the nephrologist consultants and Clinical Practice
* Obtaining informed consent

Exclusion Criteria:

* CRRT already ongoing (in another department not participating in the study) at the time of transfer/admission to intensive care;
* diagnosis of ESRF on admission;
* Discontinuation of CRRT under conditions that do not comply with the criteria established by the study;
* Need for CRRT not associated with AKI condition (e.g. elimination of toxicants);
* pregnant women;
* patient with known neoplastic disease.

Where it's running

• IRCCS Azienda Ospedaliero-Universitaria di Bologna - Anestesia polispecialistica e rianimazione
  Bologna, Bologna, Italy Recruiting
• IRCCS Azienda Ospedaliero-Universitaria di Bologna -Anestesiologia e terapia intensiva polivalente
  Bologna, Bologna, Italy Recruiting
• IRCCS Azienda Ospedaliero-Universitaria di Bologna -Anestesia e terapia intensiva cardiovascolare
  Bologna, Bo, Italy Recruiting

Study contacts

• Principal investigator: Francesco Marino, MD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
• Study coordinator: Francesco Marino, MD
• Email: francesco.marino@aosp.bo.it
• Phone: 3293842166

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.