Acute Kidney Injury in Care Transitions: A Practical Trial

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses a pragmatic design to compare a multidisciplinary intervention at care transitions against usual care for AKI survivors. It involves hospital clinicians and adult patients with KDIGO stage 2 or 3 AKI who are expected to go home after discharge. The intervention focuses on coordinated follow-up and supports at the transition from hospital to home, with Mayo Clinic as the lead site and collaboration with NIDDK. The study is conducted across Mayo Clinic sites in Minnesota and Wisconsin within a defined catchment area.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinician subjects

  * Hospital clinicians including physicians and advanced practice providers employed by Mayo Clinic and practicing at one of the four study sites
  * Provide care for hospitalized patients with stage 2 or stage 3 acute kidney injury (AKI) who are expected to be discharged home and are not receiving dialysis
* Patient subjects:

  * Adults ≥18 years old
  * Meet KDIGO consensus criteria for stage 2 (moderate) or 3 (severe) AKI
  * Residence within the study catchment area (southern Minnesota, northern Iowa, or western Wisconsin)

Exclusion Criteria:

* Clinician subjects: Physicians and advanced practice providers who:

  * Care exclusively for pediatric patients (\<18 years)
  * Care exclusively for patients on palliative care
* Patient subjects

  * Discharged to hospice care
  * Require outpatient dialysis at discharge
  * Are admitted from or expected to be discharged to a skilled nursing facility
  * Dementia Diagnosis
  * Have undergone solid organ transplant within the past 100 days
  * Decline authorization for use of their medical records for research

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting
• Mayo Clinic Health System-Mankato
  Mankato, Minnesota, United States Not yet recruiting
• Mayo Clinic Health System-Eau Claire Clinic
  Eau Claire, Wisconsin, United States Not yet recruiting

Study contacts

• Principal investigator: Erin F. Barreto, Pharm.D., Ph.D. — Mayo Clinic
• Study coordinator: Mitchell C. Strand
• Email: strand.mitchell@mayo.edu
• Phone: 507-293-0952

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Remote Ischemic Preconditioning at Different Times After Heart Valve Surgery

  This study tests whether applying brief, controlled blood-flow restrictions to a limb at different times after heart valve surgery can help protect organs and reduce complications like kidney injury.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07888634

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Biomarkers to predict CSA-AKI risk before heart surgery

  This study tests new biomarkers to see if they can predict CSA-AKI risk in adults undergoing cardiovascular surgery.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07811570

• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

  This trial tests whether using the oXiris hemofilter during continuous kidney replacement helps lower endotoxin levels in adults with septic shock who need CRRT.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07807410

• Perioperative GFR Monitoring to Predict CSA-AKI and CA-AKI

  This study tests whether perioperative transcutaneous fluorescence GFR measurements can predict CSA-AKI or CA-AKI in adults undergoing cardiovascular procedures or iodine contrast exposure.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07749417

• Restarting RAS inhibitors after AKI: a quick test in hospitalized adults

  This pilot study tests whether restarting renin-angiotensin system inhibitors early after acute kidney injury is feasible and safe in hospitalized adults already using these medicines.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07734636

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.