Using contrast-enhanced ultrasound to assess kidney function in ICU patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to quantitatively evaluate changes in renal microcirculation using contrast-enhanced ultrasound in patients diagnosed with acute kidney injury (AKI) within 24 hours of ICU admission. It will also assess systemic hemodynamic information through ultrasound Doppler simultaneously, analyzing the relationship between these two factors. The study seeks to identify quantitative parameters that reflect renal microcirculation changes and their predictive value for renal function recovery in critically ill patients. By employing advanced ultrasound techniques, the research hopes to enhance understanding of kidney function dynamics in an ICU setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>18 years old;
* AKI was diagnosed \< 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours;
* Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury;
* Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).

Exclusion Criteria:

* Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment;
* Kidney transplantation or renal malignancy;
* Terminal stage of malignant tumor;
* Pregnancy;
* Renal artery stenosis or renal vein thrombosis;
* Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or the presence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heart disease or pulmonary systolic blood pressure \>90mmHg).

Where it's running

• Department of Ultrasound Diagnosis, Peking University Third Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Ligang Cui, Dr — Department of Ultrasound, Peking University Third Hospital
• Study coordinator: Yuewei Zhang, Dr
• Email: zhang_yue_wei@126.com
• Phone: 18800109082

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing two dialysis techniques for kidney injury in ICU patients

  This study is testing whether a new dialysis method using citrate is just as good as a traditional method using heparin for helping ICU patients with kidney injury lower their urea levels.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06369064

• Remote Ischemic Preconditioning at Different Times After Heart Valve Surgery

  This study tests whether applying brief, controlled blood-flow restrictions to a limb at different times after heart valve surgery can help protect organs and reduce complications like kidney injury.

  Recruiting Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07888634

• Ultrasound-guided nasal bone fracture reduction

  This study tests whether using ultrasound to guide nasal bone fracture reduction can improve accuracy and outcomes for people with recent nasal injuries.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07869563

• Clinical decision support to help consider SGLT2 inhibitors after AKI in type 2 diabetes

  This pilot test checks if a CDS message given to clinicians can help decide whether to consider SGLT2 inhibitors for adults with type 2 diabetes who recently had acute kidney injury.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07868666

• Biomarkers to predict CSA-AKI risk before heart surgery

  This study tests new biomarkers to see if they can predict CSA-AKI risk in adults undergoing cardiovascular surgery.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07811570

• Reducing Endotoxin Burden in Septic Shock Patients on CRRT with the oXiris Filter

  This trial tests whether using the oXiris hemofilter during continuous kidney replacement helps lower endotoxin levels in adults with septic shock who need CRRT.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07807410

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.