Better ways to identify types of sudden kidney injury in U.S. Veterans
Official title: Advancing the Phenotyping of Acute Kidney Injury for the Million Veterans Program
Funded at Veterans Health Administration · NIH-11459049 · Data updated 2026-11-12
Researchers are looking for genetic and health patterns that define different types of sudden severe kidney injury in Veterans to help guide future care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2019 |
| Project end | May 31, 2026 |
| Funding year | 2026 |
| NIH project number | 5I01HX002489-08 |
| Project ID | NIH-11459049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are Veterans enrolled in the Million Veterans Program who have had, or are at risk for, acute kidney injury and have available medical records and consented genetic data.
✕Less likely to help
People who are not enrolled in the VA or the Million Veterans Program, lack genetic data, or only have stable chronic kidney disease without AKI episodes may not directly benefit from this effort.
What this research studies
You would be part of research that uses medical records and genetic information from the Million Veterans Program to separate different kinds of intrinsic acute kidney injury. The team combines lab results, procedures, and clinical details with genome-wide and predicted gene expression analyses to find biological signals linked to specific AKI subtypes. By using deeper, more precise clinical definitions rather than lumping all AKI together, they hope to reveal clearer genetic and biological causes. Those findings could help target prevention and treatments to the people most likely to benefit.
Why it matters
Potential benefit: If successful, this work could help predict who is most at risk for severe sudden kidney injury and point to more personalized prevention and treatment strategies.
How similar studies have gone: Previous genetic and clinical studies of acute kidney injury have been small and inconsistent, so this larger, genetics-focused approach is relatively novel and designed to overcome those limits.
Where this research is happening
-
Veterans Health Administration
Nashville, United States Active
Researchers
- Principal investigator: Siew, Edward D — Veterans Health Administration
- Study coordinator: Siew, Edward D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.