Cardiac Surgery Anesthesia Best Practices to Reduce Kidney Injury
Official title: Cardiac sURgery anesthesia Best practices to reduce Acute Kidney Injury (CURB-AKI)
Funded at University of Michigan at Ann Arbor · NIH-11353817 · Data updated 2026-11-12
A research project at a major university aims to reduce kidney injury after heart surgery by improving anesthesia and intraoperative care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $634,990 |
| NIH project number | 5R01DK133226-05 |
| Project ID | NIH-11353817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older undergoing cardiac surgery who are at risk for or experiencing acute kidney injury.
✕Less likely to help
Patients not undergoing cardiac surgery or without risk factors for CSA-AKI may not benefit.
What this research studies
If you or a family member has heart disease and may need surgery, this project looks at when and how kidney problems develop around the time of surgery. Researchers will analyze minute-by-minute intraoperative and early ICU data to find patterns that link anesthesia and surgical care to kidney outcomes. They will use advanced analysis to identify actionable changes in practice that could prevent kidney injury without requiring new drugs. The goal is to lower ICU stays, costs, and the risk of needing dialysis after surgery. This work could lead to clearer guidelines for anesthesiologists to protect kidney function during and after cardiac procedures.
Why it matters
Potential benefit: If successful, the project could reduce kidney injury after heart surgery, potentially shortening ICU stays and lowering costs and mortality risk.
How similar studies have gone: Prior work suggests that detailed intraoperative data can reveal patterns linked to kidney outcomes, but large-scale validation is needed.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Mathis, Michael Robert — University of Michigan at Ann Arbor
- Study coordinator: Mathis, Michael Robert
Related research
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Understanding Kidney Problems After Heart Surgery
This research looks at specific blood markers to understand why some people develop kidney problems after heart surgery, hoping to find ways to prevent it.
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Improving anesthesia practices to prevent kidney injury after heart surgery
This study is looking at how better anesthesia techniques during heart surgery can help protect your kidneys and reduce the chances of kidney problems afterward, so if you're having heart surgery, this research is all about making your recovery safer and healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.