Guided fluid removal using VeXUS score for patients with acute kidney injury after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of the VeXUS score, an ultrasound-based assessment of venous congestion, to guide fluid management in patients who have developed acute kidney injury following cardiac surgery. The goal is to determine if this targeted approach can improve patient outcomes compared to standard care. Participants will be those admitted to the intensive care unit within 72 hours post-surgery and diagnosed with acute kidney injury. The study aims to address the challenges of fluid management in this vulnerable population, where both dehydration and fluid overload can be harmful.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Intensive care unit admission within 72 hours of cardiac surgery with extracorporeal circulation
* Acute kidney injury defined by KDIGO criteria
* Vasoactive inotropic score \<45 and capillary refill time \<3s
* Informed written consent

Exclusion Criteria:

* Hypokalaemia \<3.5mmol/L
* Hyponatremia\<125mmol/L
* Hypernatremia \>145mmol/L
* Metabolic alkalosis with pH \>7.50
* Impossibility to measure capillary refill time
* Chronic liver disease
* Cirrhosis with portal hypertension
* Known thrombus of the inferior vena cava
* Mechanical circulatory assistance (ECMO or mono left ventricular assistance)
* Severe pre-operative chronic kidney disease (GFR \< 30mL/min/1.73m2)
* Need for renal replacement therapy anticipated by the attending physician within 24 hours
* Known hypersensitivity to Furosemide and/or hydrochlorothiazide
* Severe allergy to wheat
* Patient already included in another interventional study with an exclusion period still in progress
* Pregnant, breast-feeding or women of childbearing age without suitable contraception
* Patients under guardianship, curatorship or safeguard of justice
* Patients under psychiatric care
* Patients not affiliated to a social security scheme or beneficiaries of a similar scheme

Where it's running

• Hopital cardiologique Louis Pradel
  Bron, France Recruiting
• Hôpital Louis Pradel, Groupement Hospitalier Est, Hospices Civils de Lyon
  Bron, Bron, France Not yet recruiting

Study contacts

• Study coordinator: Jean-Luc Fellahi, MD
• Email: jean-luc.fellahi@chu-lyon.fr
• Phone: +334 72 31 89 44

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.